Background & Aim: Spinal cord injury (SCI) is one of the worst kinds of traumatic injuries with remarkable social and economic effects on communities.  Methods & Materials/Patients: In this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury were admitted to Poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor (G-...

Background Regaining arm and hand function was deemed the most important by quadriplegics, while regaining sexual function was given the highest priority for paraplegics. Improving bladder and bowel function was of shared importance to both injury groups. The objective of this study was to conduct a systematic review and meta-analysis of the existing research on patients with spinal cord injury...

Background and aims: One of the most common injuries around the world is the traumatic injury of the spine and spinal cord with unknown worldwide situation of traumatic spinal cord injury (TSCI) affecting on the effectiveness of preventive policy programs. In addition, because of possibility of making paralysis, the potential injury to the spine could be one of the most importa...

aspirin is an anti-inflammatory drug, peroxyl radical scavenger, and antioxidant agent that inhibits phospholipases, nitric oxide synthetases, and cyclooxygenase enzymes. the existing literature contains no studies on the effects of various doses of aspirin on spinal cord injury (sci). therefore, we sought to investigate the putative effects of aspirin on experimental sci. the weight-drop injur...

conclusions available data implies that restorative therapies should focus on multiple targets and different intervals after injury. yet, if we understand the key and basic origin of the injury, we may develop effective, complete, safe, and continual procedures. materials and methods we downloaded and reviewed more than 170 full textbooks and articles in english from the literature pubmed, and ...

spinal cord injury (sci) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. the pathophysiology of acute spinal cord injury (sci) involves primary and secondary mechanisms. neuroinflammation is an important secondary injury process in sci. the local inflammatory microenvironment within the injured spinal cord ...

introduction: spinal cord injuries are accompanied with significant demyelination of axons and subsequent locomotor dysfunction. to identify the extent of damage following electrolytic lesion of ventrolateral white matter, essential area for initiation of locomotor activity, we assessed demyelination as well as alteration in motor performance. moreover, the protective effect of estradiol as a c...

the initial experience concerning the use of magnetic resonance imaging in 94 patients who had sustained chronic cord injury showed its specific advantages over traditional imaging modalities. a variety of 84 cord abnormalities were identified including myelomalacia in 47%, cord cysts in 37%, focal atrophy in 11 % and cord transection in 5%. canal stenosis was seen in twenty-five patients, elev...

     The overall goal of this study was to identify the appropriate biomaterials able to facilitate the regeneration in rat's injured adult spinal cord. Acute damage to axons is manifested as a breach in their membranes, ionexchange distortion across the compromised region, local depolarization and even conduction block. It would be of particular importance to interrupt the progress of events h...