Group B coxsackieviruses (CVBs) are a group of common human pathogens producing various clinical symptoms. Although the virology of CVB is well known, there is limited information on viral pathogenesis and the relationship between clinical symptoms and viral phenotype, particularly for CVB type 2 (CVB2). In 2004 in Korea, two CVB2 strains were isolated: CB2/04/279 from stool of an acute myocard...

Introduction The Protection from HIV: Targeted Intervention Strategies conference was held at the Whistler Conference Center in Canada, from March 20th to 25th, this year. It was part of the meeting season in celebration of the 40th anniversary of the Keystone Symposia. Two hundred and seven researchers from all continents were present at the meeting. Current topics in viral pathogenesis, thera...

Ectopic breast tissues are subject to the similar physiological and pathological alterations seen in breast tissues situated in their normal anatomical positions. We report a 34-year old multiparous woman who presented with a right axillary lump of about 1 year duration, for which clinical impression of axillary lymphadenopathy was made and lumpectomy carried out. Histology of excised lump reve...

Defensins are innate immune effector peptides expressed at mucosal surfaces throughout the human body and are potently antiviral in vitro The role of defensins in viral pathogenesis in vivo is poorly understood; however, recent studies have revealed that defensin-virus interactions in vivo are complicated and distinct from their proposed antiviral mechanisms in vitro These findings highlight th...

Viral pathogenesis studies the mechanisms whereby a virus causes disease. More broadly, however, viral pathogenesis encompasses all the processes that occur when a virus infects a host, independently of whether disease is induced or not. Indeed, the process of infection is of interest per se, regardless of disease outcome. Moreover, it is becoming increasingly clear that viruses can interact wi...

[This corrects the article DOI: 10.1186/s13099-016-0098-0.].

Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a summary of the host genetic factors that have been demonstrated to influence the severity and chronicity of Lyme arthritis symptoms, and a review ...

Giant cell arteritis (a.k.a., Horton’s temporal arteritis) belongs to the vasculitis group of diseases and affects the great vessels, especially branches of the carotid arteries in the head. Polymyalgia rheumatica (PMR) was formerly regarded as an independent disease. Nowadays, due to shared accumulations, it is also commonly assumed that these two diseases are caused by identical pathogeneses,...

  Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, severa...