The c-Met pathway has been implicated in a variety of human cancers for its critical role in tumor growth, invasion, and metastasis. PF-04217903 is a novel ATP-competitive small-molecule inhibitor of c-Met kinase. PF-04217903 showed more than 1,000-fold selectivity for c-Met compared with more than 150 kinases, making it one of the most selective c-Met inhibitors described to date. PF-04217903 ...

Pemphigus foliaceus (PF) is an autoimmune disease characterized by blistering of the skin. Infections caused by members of the herpesviridae family have been suggested as a possible triggering factor for pemphigus vulgaris (PV), but not for PF. The present study aimed to investigate the presence of Human herpesvirus (types 1, 2, 3) in corticosteroid refractory skin lesions from a patient with P...

Pemphigus foliaceus (PF) is an organ-specific autoimmune skin disease characterized by subcorneal epidermal cell detachment (acantholysis) and pathogenic autoantibodies against desmoglein 1. The mechanism responsible for pemphigus autoantibody-induced epidermal injury is not fully understood. In this study, we used the IgG passive transfer mouse model of PF to investigate the relevance of the a...

The leaves and stems of Perilla frutescens var. acuta Kudo (PF) have been used to prevent threatened abortion in traditional medicine in the East Asian countries. Because reduced receptivity of endometrium is a cause of abortion, we analyzed the action of PF on the endometrial receptivity. PF increased the level of leukemia inhibitory factor (LIF), a major cytokine regulating endometrial recept...

INTRODUCTION The information obtained from the Emergency Medical Chart (EMC) is a key factor for the correct management of acute stroke. Our aim is to determine if the use of a pro-forma (PF) for filling in the EMC improves the quality of the clinical information. MATERIAL AND METHODS A PF was created from a list of 26 key-items considered important to be recorded in an EMC. We compared the n...

background: precise diagnosis of disease risk factors via efficient statistical models is the primary step for reducing the heavy costs of breast cancer, as one of the most highly prevalent cancer throughout the world. therefore, the aim of this study was to present a recently introduced statistical model in order to assess its proficiency for model fitting. methods: the information of 1465 eli...

The present investigation entails a procedure by which the surface tension and viscosity of liquids could be redicted.To this end, capillary experiments were performed for porous media by utilizing fifteen different liquids and powders. The time of capillary rise to a certain known height of each liquid in a particular powder was recorded. Two artificial neural networks (ANNs) were...

In this paper, we propose a novel H-infinity filter based particle filter (H∞PF), which incorporates the H-infinity filter (H∞F) algorithm into the particle filter (PF). The basic idea of the H∞PF is that new particles are sampled by the H∞F algorithm. Since the H∞F algorithm can fully take into account the current measurements, when the new algorithm calculates the proposed probability density...

AIM/HYPOTHESIS The etiology of plantar fasciitis (PF) has been related to several risk factors, but the magnitude of the plantar load is the most commonly described factor. Although PF is the third most-common injury in runners, only two studies have investigated this factor in runners, and their results are still inconclusive regarding the injury stage. OBJECTIVE Analyze and compare the plan...