Treatment of six cases of missed abortion and one case of hydatidiform mole with intravenous infusion of prostaglandin E(2) resulted in complete abortion in all cases. Of 15 patients with missed labour, 14 were delivered successfully with similar treatment. The technique appears to be a safe, reliable, and rapid method of managing missed abortion, missed labour, and hydatidiform mole.

Gestational trophoblastic diseases (GTDs) are a group of diseases characterized by abnormal cellular proliferation of atypical trophoblasts. A hydatidiform mole is an abnormal pregnancy caused by genetic fertilization disorders, and it can be classified as a complete hydatidiform mole (CHM) or a partial hydatidiform mole. The aim of this study was to establish cell lines from CHMs and to charac...

There are various causes of hyperthyroidism in pregnancy such as Graves' disease and gestational thyrotoxicosis. The thyroid stimulation results from the excessive levels of circulating human chorionic gonadotropin (hCG) produced by the trophoblastic tissue in both hydatidiform moles and choriocarcinoma. We present a pregnant patient with hydatidiform mole who presented with hyperthyroidism tha...

Placental mesenchymal dysplasia (PMD) is a rare placental disorder characterized by placental enlargement and areas of abnormal, enlarged, grape-like villi. This condition may resemble a partial hydatidiform mole and may occur associated with Beckwith-Wiedemann syndrome (BWS) or in phenotypically normal fetuses. There were 110 cases reported so far. We describe one case with typical gross and m...

Recurrent hydatidiform mole is defined as episodes of two molar pregnancies in a female. Often, complete moles onlyderive androgenic nuclear genome. We described two cases with repeated molar pregnancies attempted to preventfuture episodes by performing intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD)to assess genetic disorders. The first pat...

BACKGROUND Classification of molar gestation into Complete Hydatidiform Mole (CHM) and Partial Hydatidiform Mole (PHM) is done according to clinical, ultrasonographic, histologic and genetic criteria. However, making a distinction between CHM and PHM using histologic criteria alone may be difficult and several studies have shown that misclassifications are frequent, even for experienced patholo...

HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocarcinoma. The aim of the study is to investigate the expression of HtrA1 in thes...

or hyperemesis. Detailed Ultrasound examination with 4 MHZ transabdominal & 7 MHz endocavity transducers (Acuson-Aspen), revealed a normal fetus of 21 weeks with no congenital anomalies. But there was a large co existing intrauterine hypoechoic mass with multiple anechoic spaces, along the posterior wall. A small normal placenta was seen adjacent to the mass. A presumptive diagnosis of Hydatidi...