Non-Hodgkin’s lymphomas constitute 25 to 40% of all lymphomas. The gastrointestinal tract is the most common site followed by the head and neck area. Salivary gland involvement is a very rare entity and is involved in 0.5 to 5% of all cases. Among all the major salivary glands, the parotid gland is commonly involved followed by the submandibular glands. Misdiagnosis often leads to unnecessary d...

BACKGROUND To identify prognostic factors in patients with parotid gland carcinomas who were treated at the Princess Margaret Hospital. METHODS Clinical outcome of two hundred fifteen patients with malignancies of the parotid gland was evaluated over a 16-year period. RESULTS Two-hundred-fifteen patients with adenoid cystic carcinoma (n = 20), adenocarcinoma (n = 19), acinic cell carcinoma ...

BACKGROUND Our aim was to review the presentation, treatment, and outcome of patients with metastatic cutaneous squamous cell carcinoma involving the parotid gland at a tertiary referral center. METHODS We performed a retrospective chart review of the cancer registry at the Princess Margaret Hospital, Toronto, from 1970 to 2001. All patients had a previously untreated metastatic cutaneous hea...

OBJECTIVE To identify features present at diagnosis that were prospectively associated with adverse outcomes in a large cohort of patients with primary Sjögren's syndrome (SS). METHODS Two hundred and sixty-six patients diagnosed with primary SS in our department between 1984 and 2002 were consecutively included and followed up. Outcomes measured were vasculitis, B-cell lymphoma and death. Co...

OBJECTIVES/HYPOTHESIS To examine the significance of indeterminate fine needle aspiration biopsy in the diagnosis of parotid gland malignancy. STUDY DESIGN Retrospective case series, academic tertiary referral center. METHODS A total of 559 parotidectomies performed between the years of 2005 and 2010 were reviewed, with 56.7% (N = 317) meeting investigation eligibility criteria: primary par...

We report on a patient with biopsy proven systemic Wegener's granulomatosis (WG) with a granulomatous necrotising manifestation of WG in the liver, lung, parotid gland and skin with subsequent death of liver failure. Liver involvement in WG is an exceedingly rare, though potentially fatal, organ manifestation of WG.

Primary lymphomas arising from the parotid gland are uncommon and usually account for only 0.6–5% of tumors or tumor-like lesions of the parotid, and therefore are commonly overlooked. Most cases involve the major salivary glands, primarily the parotid (50-93%) and the submandibular glands [1]. The misdiagnosis often leads to unnecessary diagnostic procedures thereby delaying the initiation of ...

Granulomatosis with polyangiitis (GPA) is a small-vessel vasculitis consisting of necrotizing granulomatous lesions in airways and focal necrotizing glomerulonephritis. However, it may affect other sites such as the skin, central nervous system, eyes, heart, gastrointestinal tract, and liver. We describe a rare case of GPA in which the initial manifestation was the involvement of the parotid gl...

BACKGROUND Early onset sarcoidosis is a rarely reported disease in children. CASE CHARACTERISTICS 2½-year-old girl with chronic enlargement of bilateral parotid glands and polyarthritis. OBSERVATION Biopsy of salivary gland revealed non-caseating granuloma. OUTCOME Polyarthritis and salivary gland swelling resolved completely after starting oral corticosteroids. MESSAGE Sarcoidosis is a...