because of continuous changing of anatomy, function and metabolism of the human brain, age- related change is a major risk factor in most prevalent neurodegenerative diseases, including parkinsons and huntingtons disease. therefore, knowing patterns of age-related atrophy of brain tissue can identify causes and possible role of diseases in decreasing brain function with age. the aim of this stu...

One of the characteristic symptoms of patients with Parkinson Disease (PD) is a rigidity of movement. These symptoms disappear after administration of Levodopa. However, the long-term use of levodopa causes involuntary movements (dyskinesia). A proper diagnosis requires an automatic, unsupervised method for the detection and classification of levodopa induced dyskinesia. The main problem, howev...

INTRODUCTION In search for a suitable rat model to study potentially affected blood-brain barrier (BBB) transport mechanisms in the course of Parkinsons disease (PD) progression, experiments were performed to characterise Parkinsons disease markers following subcutaneous (SC) and intracerebral (IC) infusion of the toxin rotenone in the rat. METHODS Studies were performed using Male Lewis rats...

Adaptation in the sensory-mechanical loop during locomotion is a powerful mechanism that allows organisms to survive in different conditions and environments. For example, humans can walk on earth gravity, but they switch to hopping on, for example, moon gravity. The nematode Caenorhabditis elegans also shows adaptability by employing thrashing behaviour in low viscosity media and crawling in h...

Computer vision is a fast developing field of science, that comprises gait monitoring, which is the main focus of our appication. on gait monitoring and analysis. The novelty of this work is combining MS Kinect v2 sensor for capturing the gait pattern and a robotic platform, thus having a mobile device. Crucial part of this project is the hardware solution and autonomous function of the aforeme...

A case of parkinson's disease starting 7 yrs. ago in 1993 with 2 episodes of mania is presented. The 1st episode (1993) was of 1-1/2 months duration, when early parkinsons symptoms had already set in. This was treated with anti-psychotic medications for a month, the picture was complicated with stroke and post-stroke sequlae for 5-6 months, where anti-psychotics were continued. He developed dys...