BACKGROUND Commonly used vision-targeted health-related quality of life questionnaires almost exclusively focus items on vision under daytime conditions. Older adults even when in good eye health frequently report experiencing vision problems at night and under low environmental light levels, and psychophysical studies also document these visibility problems. Here we compare the progression of ...

Agglomerative algorithms iteratively pick a pair of taxa, create a new node that represents the cluster of these taxa, and compute a new distance matrix with reduced size where both taxa are replaced by this node. The cycle is repeated until the number of taxa becomes three (or two for rooted trees). This general scheme was first applied to additive unrooted trees by Sattath and Tversky (ADDTRE...

One of the goals of the recent workshop, “An Eye on Glaucoma: New Opportunities for Treatment,” was to highlight areas of glaucoma research that, with appropriate funding, are ripe for major advancement for prevention, diagnosis, and treatment. Another goal was the exploration of collaborative partnership and the process for facilitating translation of these areas, not just for glaucoma but for...

Purpose. To evaluate the relationship between self-reported vision-related quality of life (VRQL) and visual field (VF) loss in people from glaucoma clinics. Methods. A postal survey using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was administered to people with a range of VF loss identified from a UK hospital-based glaucoma service database. Trends were assessed in ...

The oxidation and deamination of 5-methylcytosine (5mC) in DNA generates a base-pair between 5-hydroxymethyluracil (5hmU) and guanine. 5hmU normally forms a base-pair with adenine. Therefore, the conversion of 5mC to 5hmU is a potential pathway for the generation of 5mC to T transitions. Mammalian cells have high levels of activity of 5hmU-DNA glycosylase, which excises 5hmU from DNA. However, ...

The 5-formyluracil (5-foU), a major mutagenic oxidative damage of thymine, is removed from DNA by Nth, Nei and MutM in Escherichia coli. However, DNA polymerases can also replicate past the 5-foU by incorporating C and G opposite the lesion, although the mechanism of correction of the incorporated bases is still unknown. In this study, using a borohydride-trapping assay, we identified a protein...

PURPOSE To determine the relationship between the American Medical Association's (AMA) functional vision score (FVS) and vision-specific quality of life in retinitis pigmentosa (RP) patients using the National Eye Institute's Visual Functioning Questionnaire (NEI-VFQ 25). METHODS One hundred eight patients with RP participated in the study. We measured best-corrected visual acuity, conducted ...

Review Question/Objective L'obiettivo è di presentare le migliori evidenze disponibili sull'uso della contenzione fisica per prevenire l'autorimozione dei presidi nei pazienti adulti critici Background La ragione principale per l'uso della contenzione fisica in terapia intensiva è quello di proteggere i pazienti dall' auto-rimozione dei dispositivi terapeutici. Anche se la contenzione fisica è ...

AIMS To assess the relationship between depression and the vision-related quality of life in patients with retinitis pigmentosa (RP). METHODS The study included 144 patients diagnosed as having RP. The mean age of the patients was 38.5 (SD 13.3) years, and 42% of the subjects were women. They answered the National Eye Institute Visual Function Questionnaire (NEI-VFQ) to assess the vision-rela...