conclusions the present study has demonstrated that a combination of exercise and silymarin can improve body composition and adiponectin levels. background silymarin has powerful antioxidant properties, but its effects on athletic performance are poorly understood. objectives the present study was undertaken to evaluate the effects of 4 weeks of endurance or strength exercise, with or without s...

candidate genetic risk factor for vascular disease. A common mutation in methylenetetrahydrafolate reductase. Nat Genet 1995;10:111–3. 9. Virgos C, Joven J, Simo JM, Vilella E, Camps J, Arcelus R, et al. Homocyst(e)ine and the C677T mutation of methylenetetrahydrofolate reductase in survivors of premature myocardial infarction. Clin Biochem 2000;33:509– 12. 10. Hixson JE, Vernier DT. Restrictio...

The aim of this study was to determine whether the paraoxonase (PON1) status, i.e. PON1 activities and phenotypes (AA, AB and BB), and its relationship with lipid status are different in patients with type II diabetes as compared to healthy population. Diabetic group comprised 175 patients with type II diabetes mellitus (94 men and 81 women) who came to their regular control examination and too...

INTRODUCTION Serum paraoxonase-1 (PON1) retards the oxidation of low-density lipoprotein and cell membranes and is atheroprotective. Polymorphisms in the promoter region of the PON1 gene have been shown to affect serum PON1 levels and have been related to the presence of coronary heart disease (CHD) in some studies. However, contradictory results have been reported with regard to promoter regio...

BACKGROUND Toxicity of organophosphate insecticides is mainly due to the inhibition of acetylcholinesterase (AChE). However, organophosphate insecticides in acute, as well as in chronic and subchronic intoxication may lead to oxidative stress causing the enhancement of lipid peroxidation and changing the activities of antioxidative enzymes. Paraoxonase PON1 is synthesized by the liver. This enz...

We have evaluated the possible association of polycystic ovary syndrome (PCOS) with 15 genomic variants previously described to influence insulin resistance, obesity, and/or type 2 diabetes mellitus. Seventy-two PCOS patients and 42 healthy controls were genotyped for 15 variants in the genes encoding for paraoxonase (three variants), plasma cell differentiation antigen glycoprotein, human sorb...

The existence of two or more enzyme forms with paraoxonase activity has been reported in sheep, rabbit, human and rat serum and recently in mouse and rat liver. In this study we describe the presence of two peaks with paraoxonase activity (M1 and M2) after non-specific affinity chromatography of rat liver microsomes on Cibacron Blue 3GA. The first peak (M1) was obtained during the washing of th...

BACKGROUND AND PURPOSE Genetic polymorphism at the paraoxonase locus is associated with serum concentration and activity of paraoxonase and with increased risk for coronary heart disease. Two frequent polymorphisms present at the paraoxonase gene are the methionine (M allele) leucine (L allele) interchange at position 54 and the arginine (B allele) glutamine (A allele) interchange at position 1...

BACKGROUND & OBJECTIVES Paraoxonase (PON) is an HDL associated ester hydrolase with an ability to retard LDL oxidation in vitro by preventing lipid peroxide generation. The population variability in enzyme activity is attributed to polymorphisms in paraoxonase gene. For example, polymorphism at codon 192 and 55 of the paraoxonase gene has been reported to be associated with coronary heart disea...