We describe a patient with small cell lung cancer with anti-Hu paraneoplastic cerebellar degeneration and central hypoventilation syndrome. This highlights the insidious clinical presentation of central hypoventilation and raises awareness of this condition as a paraneoplastic phenomenon. This case also highlights the complex circuitry of automatic respiration in the brainstem and the potential...

Seborrheic keratoses can often be found in elderly people. In general, they appear gradually. In cases of a sudden eruption with itching it might be paraneoplastic. Although some authors doubt the existence of the paraneoplastic Leser-Trélat syndrome, we present a case of sudden eruption of seborrheic keratoses connected with a newly diagnosed renal cell carcinoma. As far as we know, this is th...

We can define paraneoplastic syndromes as a combination of effects occurring far from the original location of the tumour and independently from the local repercussion of its metastases. Paraneoplastic hormonal syndromes depend on the secretion of hormonal peptides or their precursors, cytokines and, more rarely, thyroidal hormones and Vitamin D, which act in an endocrine, paracrine or autocrin...

Paraneoplastic glomerulopathies are rare manifestations of neoplastic disease to be distinguished from iatrogenic renal damage. Solid tumors are preferentially associated with membranous nephropathy, whereas Hodgkin's lymphomas are associated with minimal change disease. The most common neoplasia associated with paraneoplastic glomerular disease are carcinomas of the lung and of the gastrointes...

Paraneoplastic neurologic syndrome (PNS) is a rare group of disorders caused by nervous system damages in the setting of cancer unrelated to the tumor sites. It may affect one or more regions of the nervous system and occurred in less than 1 per 10,000 patients diagnosed with a malignancy. Patients with PNS may present symptoms or damages in the central and peripheral nervous system, the neurom...

INTRODUCTION Lung cancer is the leading cause of death among the cancers seen in the United States. Hypercalcemia and leukocytosis are two common paraneoplastic syndromes associated with lung cancer. Unfortunately patients presenting with Hypercalcemia- leukocytosis syndrome has a worse prognosis than patients presenting with lung cancer alone. CASE PRESENTATION We present a 67 yr old Caucasi...

IMPORTANCE Purkinje cell cytoplasmic antibody type 1 (PCA-1)-IgG (or anti-Yo) is characteristically detected in women with gynecological or breast adenocarcinoma. We describe 2 unique scenarios occurring in 1 patient: PCA-1 paraneoplastic autoimmunity in a child, and a paraneoplastic neurological disorder in the context of Down syndrome. OBSERVATIONS A child with Down syndrome and a history o...

Paraneoplastic nephropathy is a rare complication of malignant disease. We present a case of cervical cancer with biopsy-proven membranous nephropathy and associated nephrotic syndrome. Irradiation to the specific neoplasm site and to the metastatic paraaortic lymph node tissues lead to regression of the nephrotic syndrome without causing severe adverse events. Radiation therapy can be the firs...

Julie Lemieux, Louise Provencher, Denis Brunet, Jean-Charles Hogue Quebec City, QC, Canada REFERENCES 1. Toothaker TB, Rubin M. Paraneoplastic neurological syndromes: a review. Neurologist. 2009;15(1):21-33. 2. Murinson BB. Stiff-person syndrome. Neurologist. 2004;10(3): 131-7. 3. Gordon EE, Januszko DM, Kaufman L. A critical survey of stiffman syndrome. Am J Med. 1967;42(4):582-99. 4. Solimena...