amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Advances in materials science, chemistry, and self-assembly are anticipated to enable the fabrication of massively parallel computer systems. An important aspect of this development is the design and evaluation of system-level interactions and performance based on the fundamental properties of emerging nanoscale devices on real computer applications. This paper will present the design, evaluati...

We establish a variety of combinatorial bounds on the tradeoos inherent in reconstructing strings using few rounds of a given number of substring queries per round. These results lead us to propose a new approach to sequencing by hybridization (SBH), which uses interaction to dramatically reduce the number of oligonucleotides used for de novo sequencing of large DNA fragments, while preserving ...

The commercial off the shelf (COTS) twelve channel optical fiber MTP array connector and ribbon cable assembly is being validated for space flight use and the results of this study to date are presented here. The interconnection system implemented for the Parallel Fiber Optic Data Bus (PFODB) physical layer will include a 100 /140 micron diameter optical fiber in the cable configuration among o...

This article presents the results of a numerical study, using computational fluid dynamics (CFD) analysis to investigate the species distribution of proton exchange membrane fuel cells (PEMFCs) with deflected membrane electrode assembly (MEA). These new geometry were examined while employing three-dimensional, single phase, non-isothermal and parallel flow for model of a PEM fuel cell. This num...

Programmable 3D cell assembly under physiological pH conditions is achieved using electrodeposited stimuli-responsive alginate gels in a microfluidic device, with parallel sidewall electrodes enabling direct observation of the cell assembly. Electrically triggered assembly and subsequent viability of mammalian cells is demonstrated, along with spatially programmable, multi-address assembly of d...

A new hybrid assembly line design, called Parallel U-shaped Assembly Line system, is introduced and characterised along with numerical examples for the first time. Different from existing studies on U-shaped lines, we combine the advantages of two individual line configurations (namely parallel lines and U-shaped lines) and create an opportunity for assigning tasks to multi-line workstations lo...

In this paper we study an assembly line balancing problem that occurs in sheltered worker centers for the disabled, where workers with very different characteristics are present. We are interested in the situation in which complete parallel assembly lines are allowed and name the resulting problem as parallel assembly line worker assignment and balancing problem (PALWABP). This approach enables...