BACKGROUND Paracetamol self-poisoning, which carries a significant risk of fatal liver damage, is increasing in the UK, especially among adolescents. There is concern that media portrayal of suicidal behaviour may influence its occurrence. We have investigated the effects of two broadcasts of a television drama showing a teenage girl's overdose of paracetamol. METHOD Data from the Oxford Moni...

CASE REPORT. A 16-year old boy was admitted following an overdose of 48 tablets of diclofenac 100 mg, 20 tablets of codeine phosphate 30 mg and 40 tablets of paracetamol 500 mg. He was alert and felt well on admission. General examination was normal. His serum paracetamol level on arrival was 34 mg/I, which did not justify treatment with acetyl cysteine. Serum sodium, potassium and urea were no...

Silymarin (Sm) is a polyphenolic component extracted from Silybum marianum. It is an antioxidant, traditionally used as an immunostimulant, hepatoprotectant, and dietary supplement. Relatively recently, Sm has proved to be a valuable chemopreventive and a useful antineoplastic agent. Medical success for Sm is, however, constrained by very low aqueous solubility and associated biopharmaceutical ...