Previous studies have shown that protease-activated receptors (PARs) play an important role in various physiological processes. In the present investigation, we determined the expression of PARs on human lung fibroblasts (HLF-1) and whether they were involved in cellular differentiation and pro-inflammatory cytokine and prostaglandin (PGE2) secretion. PAR-1, PAR-2, PAR-3, and PAR-4 were detecte...

The conserved PAR proteins are localized in asymmetric cortical domains and are required for the polarized localization of cell fate determinants in many organisms. In Caenorhabditis elegans embryos, LET-99 and G protein signaling act downstream of the PARs to regulate spindle positioning and ensure asymmetric division. PAR-3 and PAR-2 localize LET-99 to a posterior cortical band through an unk...

Activation of both PAR-1 (proteinase-activated receptor-1) and PAR-2 resulted in release of the chemokine GRO (growth-regulated oncogene)/CINC-1 (cytokine-induced neutrophil chemoattractant-1), a functional counterpart of human interleukin-8, from rat astrocytes. Here, we investigate whether the two PAR receptor subtypes can signal separately. PAR-2-induced GRO/CINC-1 release was independent of...

The prostate apoptosis response-4 (par-4) gene was identified by differential screening for genes that are upregulated when prostate cancer cells are induced to undergo apoptosis. The par-4 gene is induced by apoptotic signals but not by growth-arresting, necrotic, or growth-stimulatory signals. The deduced amino acid sequence of par-4 predicts a protein with a leucine zipper domain at its carb...

l'utilisation des fluctuations statistiques des signaux analogiques fournis par les detecte urs neutroniques pour ameliorer la discrimination neutron _gamma a ete suggeree pour la premiere fois par «lichtenstein» en 1955. un detecteur soumis a'un rayonnemet libere, en moyenne, n impultions par seconde caracterisees par leur charge q. si l' on integre ces impultions dans une cellu...

eperisone hydrochloride is a skeletal muscle relaxant and paracetamol is cyclooxygenase inhibitor. these drugs in combination are used as antispasmodics. a simple, specific, precise and accurate method was developed, namely reverse phase high performance liquid chromatography for simultaneous estimation of eperisone hydrochloride and paracetamol in tablet dosage form. in rp-hplc method separati...

la question de l’interaction entre le lecteur et le personnage est cruciale en toute étude en littérature fictionnelle. pourtant, malgré l’intérêt que les chercheurs portent depuis longtemps à l’examen de cette relation, celle-ci n’a été que rarement l’objet d’une étude méthodique. c’est pour combler ce manque que vincent jouve propose sa théorisation sur « l’effet-personnage ». le modèle prése...

Wireless networks have experienced drastic evolutions in the last few years. While many aspects related to “single cell” wireless networks were already resolved, wireless multihop networks still suffer poor performances and limited capacities. This thesis aims at providing acceptable quality of service in terms of throughput and loss ratio to end users in various wireless multihop environments....