We investigated the association of metabolic syndrome (MetS) with a 500 k and a 50 k single-nucleotide polymorphism (SNP) gene chip in the Framingham Heart Study. We cross-sectionally evaluated the MetS longitudinal trends. Data analyzed were from the Offspring Cohort (four exams: first (n = 2,441), third (n = 2,185), fifth (n = 2,308), and seventh (n = 2,328)) and the Generation 3 Cohort (one ...

We introduce a new diagrammatic approach to quantum information, that we call holographic software [1]. Our new approach is a small modification of previous diagrammatic approaches, yet our small change leads to a great deal of new understanding and to a large number of new insights and motivation. Its application leads us to new protocols, designed in a “topological” way. (1) The fundamental i...

BACKGROUND Analysis of circulating RNA in the plasma of pregnant women has the potential to serve as a powerful tool for noninvasive prenatal testing and research. However, detection of circulating RNA in the plasma in an unbiased and high-throughput manner has been technically challenging. Therefore, only a limited number of circulating RNA species in maternal plasma have been validated as pre...

Background: Pre-eclampsia is hypertensive disorder with several complications. Contributes to increased maternal mortality and morbidity. associated pre term labour, IUGR other complications like end organ failure in mother. So, it important diagnose early take appropriate steps mitigate Aim was detect predict preterm pre-eclampsia using extended first trimester screening test pregnant women. O...

Ewing sarcoma is an aggressive cancer of bone and soft tissue in children with poor prognosis. It is characterized by the chromosomal translocation between EWS and an Ets family transcription factor, most commonly FLI-1. EWS-FLI-1 fusion accounts for 85% of Ewing sarcoma cases. EWS-FLI-1 regulates the expression of a number of genes important for sarcomagenesis, can transform NIH3T3 and C3H10T1...

OBJECTIVES To determine if maternal serum levels of 25(OH)D at 11-13 weeks' gestation are altered in pregnancies that subsequently deliver small for gestational age (SGA) neonates and whether the levels are related to placental function reflected in serum concentration of pregnancy-associated plasma protein-A (PAPP-A). METHODS Serum 25(OH)D and PAPP-A were measured at 11-13 weeks in 150 singl...

Microarray gene expression profiling has been used to distinguish histological subtypes of renal cell carcinoma (RCC), and consequently to identify specific tumor markers. The analytical procedures currently in use find sets of genes whose average differential expression across the two categories differ significantly. In general each of the markers thus identified does not distinguish tumor fro...

At present there is a wide range of data mining algorithms available to researchers and practitioners (Witten & Frank, 2005; Tan et al., 2006). Despite the great diversity of these algorithms, virtually all of them share one feature: they have been manually designed. As a result, current data mining algorithms in general incorporate human biases and preconceptions in their designs. This article...

C-type dorsal root ganglion (DRG) neurons express three types of Na+ currents: fast TTX-sensitive, slow TTX-resistant, and persistent TTX-resistant Na+ currents. The nitric oxide (NO) donors papa-NONOate and S-nitroso-N-acetyl-DL-penicillamine inhibit all three types of Na+ currents. The NO scavenger hemoglobin abolished the effects of papa-NONOate on Na+ currents, indicating that NO or NO-rela...