Haemophilus influenzae haemagglutinating pili are surface appendages that promote attachment to host cells and facilitate respiratory tract colonization, an essential step in the pathogenesis of disease. In contrast to other well-characterized forms of pili, H. influenzae haemagglutinating pili are two-stranded helical structures. Nevertheless, haemagglutinating pili are assembled by a pathway ...

Introduction De novo protein design and architecture both focus on the construction and design of three-dimensional structures. Although these disciplines work on vastly different scales, they nevertheless share two requirements: a structural design and an understanding of the physical properties which govern the stability of that structure. Our knowledge of physics and engineering has allowed ...

Brain homogenates from young rats were assayed for their ability to synthesize cerebrosides from radioactive UDP-galactose or UDP-glucose and ceramide. A comparison of galactose transfer with ceramides made from different 2-hydroxy acids showed that the shortest one tested (C,) was by far the best acceptor, while the poorest contained 18 carbon atoms; longer fatty acids were better than CIS. Gl...

Non-coding RNAs (ncRNAs), especially for microRNAs (miRNAs), have been widely s tudied as crucial negative regulatory molecules. Long noncoding RNAs (lncRNAs) also have attracted the attention of researchers due to their potential contribution in multiple essential biological processes. To understand th e p otential in teractions between miRNAs, l ncRNAs and mRNAs a nd their p otential r oles i...