Background: Hylomecon japonica, a plant of the Papaveraceae family which is well-known for the alkaloids they produce, is a perennial plant widely distributed in the northeast, central and east regions of China. Although a variety of chemical constituents, including alkaloids, flavonoids, and megastigmoids, have been isolated from H. japonica, the investigation of saponins in H. japonica has no...

The Papaveraceae represent a large family divided into 23 genera with more than 300 species, distributed world-wide in subtropical and temperate regions (Reveal, 1999). The genus Papaver L. is represented by more than 120 species, rich in isoquinoline and morphinane alkaloids (Preininger, 1986). In our previous phytochemical studies on Papaver nudicaule L. growing in Mongolia, we reported the i...

Signal transducer and activator of transcription 3 (STAT3) plays a key role in promoting tumor malignant progression. Suppression hyperactivated STAT3 signaling has emerged as potential therapeutic strategy for many cancer types. In this study, the effect 6-ethoxydihydrosanguinarine (6-EDS), secondary transformation product formed from dihydrosanguinarine, isolated Macleaya (Papaveraceae), was ...