Opium poppy (Papaver somniferum) produces medicinally important benzylisoquinoline alkaloids, including the analgesics codeine and morphine, in the morphinan pathway. We aligned three dioxygenases that were recently discovered in P. somniferum and subsequently identified the nonconserved regions. Two of these enzymes, codeine O-demethylase (PsCODM) and thebaine O-demethylase (PsT6ODM), are know...

Over the course of human history, it has been common to use plants for medicinal purposes, such as for providing relief from particular maladies and self-medication. Opium represents one longstanding remedy that has been used to address a range of medical conditions, alleviating discomfort often in ways that have proven pleasurable. Opium is a combination of compounds obtained from the mature f...

Noscapine is a potential anticancer drug isolated from the opium poppy Papaver somniferum, and genes encoding enzymes responsible for the synthesis of noscapine have been recently discovered to be clustered on the genome of P. somniferum. Here, we reconstitute the noscapine gene cluster in Saccharomyces cerevisiae to achieve the microbial production of noscapine and related pathway intermediate...

Medicinal use of the opium poppy (Papaver somniferum L) has ancient history, but the isolation of morphine was not described until the early nineteenth century. Morphine is the most important alkaloid of opium poppy in the last 50 years. In the morphine pathway has been reported to generate morphine in this species, CODM has a crucial role as the gene coding the enzyme respons...

DRUG ADDIcTIoN, especially through the use of poppy (Papaver somniferum Linn.) and hemp (Cannabis sativa Linn.), is the main concern of this paper. Although the use of these two plants in medieval Islam was extensive, yet little has been written on this timely subject by historians of medicine and pharmacology. Consulting contemporary original sources, it is my hope to sketch a history of their...

In this research there were studied the effects of NaCl-induced salinity and environment temperatures on germination seedlings growth domestic poppy. The study was conducted in controlled conditions plant chamber. There applied different concentrations NaCl (0 mM (control), 50 mM, 100 150 mM) (10°C, 15°C 20°C). seeds poppy cultivar (Detkovac) sown 4 replicates filter paper. energy determined 5t...