Previous research suggests that many preschoolers meet criteria for psychiatric diagnoses; still, relatively little is known about preschool mental health, particularly emotional problems, in the community. This study investigated the rates of parent-reported DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision) disorders in a large community sample of pr...

Experimental data from wind-tunnel tests of the Rigid Semispan Model (RSM) performed at NASA Langley's Transonic Dynamics Tunnel (TDT) are presented. The primary focus of the paper is on data obtained from testing of the RSM on the Oscillating Turntable (OTT). The OTT is capable of oscillating models in pitch at various amplitudes and frequencies about mean angles of attack. Steady and unsteady...

To better understand the mechanism(s) underlying nitric oxide (. NO)-mediated toxicity, in the presence and absence of concomitant oxidant exposure, postmitotic terminally differentiated NT2N cells, which are incapable of producing. NO, were exposed to PAPA-NONOate (PAPA/NO) and 3-morpholinosydnonimine (SIN-1). Exposure to SIN-1, which generated peroxynitrite in the range of 25-750 nM/min, prod...

In isolated adipocytes, the nitrosothiols S-nitroso-N-acetyl-penicillamine (SNAP) and S-nitrosoglutathione stimulate basal lipolysis, whereas the nitric oxide (NO.) donor 1-propamine, 3-(2-hydroxy-2-nitroso-1-propylhydrazine) (PAPA-NONOate) or NO gas have no effect. The increase in basal lipolysis due to nitrosothiols was prevented by dithiothreitol but not by a guanylate cyclase inhibitor. In ...

BACKGROUND The overuse of antibiotics is becoming an increasing concern. Antibiotic resistance, which increases both the burden of disease, and the cost of health services, is perhaps the most profound impact of antibiotics overuse. Attempts have been made to develop instruments to measure the psychosocial constructs underlying antibiotics use, however, none of these instruments have undergone ...

I n humans, IRE1 is central to one of three pathways that sense the presence of misfolded proteins in the ER, initiating early steps of the unfolded protein response (UPR). ER stress induces IRE1 multimerization and activation of its cytoplasmic RNase domain, which then cleaves the RNA encoding the transcription factor XBP1. This cleavage step allows XBP1's translation into protein so that it c...

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Neutron stars are perhaps the most promising class of gravitational wave (GW) sources, and searches for such GW signals is particularly suited to the characteristics of the GEO600 detector (see Schutz “Getting Ready for GEO600 Data” gr–qc9910033). However, the instantaneous GW frequency of such a source will evolve due to both intrinsic spindown effects and Doppler modulations induced by the mo...

Results RCTs provide evidence for rilonacept and canakinumab in CAPS, colchicine in FMF and (adeno)tonsillectomy in PFAPA syndrome. For Behçet disease, RCTs have been conducted on the effect of several drugs, including colchicine, azathioprine, cyclosporine A, interferon alfa, etanercept, sucralfate suspension and pimecrolimus. Descriptive studies suggest that NSAIDs and corticosteroids are hig...