Glioblastoma brain tumor cells and normal cells were treated with plasma-activated medium (PAM). Cell proliferation assays showed that glioblastoma cells were selectively killed by PAM. PAM induced apoptosis on glioblastoma. There are many signaling pathways that lead to apoptosis. We found that PAM downregulated the PI3K/PTEN-AKT pathway that is responsible for cell survival and proliferation ...

We propose a family of Passive-Aggressive Mahalanobis (PAM) algorithms, which are incremental (online) binary classifiers that consider the distribution of data. PAM is in fact a generalization of the Passive-Aggressive (PA) algorithms to handle data distributions that can be represented by a covariance matrix. The update equations for PAM are derived and theoretical error loss bounds computed....

Building on its high spatial resolution, deep penetration depth and excellent image contrast, 3D photoacoustic microscopy (PAM) has grown tremendously since its first publication in 2005. Integrating optical excitation and acoustic detection, PAM has broken through both the optical diffusion and optical diffraction limits. PAM has 100% relative sensitivity to optical absorption (i.e., a given p...

We report the synthesis of new polymers based on a dimethylacrylamide-methacrylate (DMAA-MA) co-polymer backbone that support both chemical and biological agent decontamination. Polyurethanes containing the redox enzymes glucose oxidase and horseradish peroxidase can convert halide ions into active halogens and exert striking bactericidal activity against gram positive and gram negative bacteri...

We propose a formal procedure-based agent model for plan recognition as an alternative to the declarative proposition-based agent model. Our formalism, called the Procedural Agent Model (PAM) allows us to describe procedural plans of agents in a concise and abstract way. Plan recognition uses PAM as a library of plan schemas and applies a graph-based pattern-matching algorithm to the observed e...

Prior results show that most bounded query hierarchies cannot contain finite gaps. For example, it is known that PSAT (m+1)-tt = PSAT m-tt ) PSAT btt = PSAT m-tt and for all sets A FPA(m+1)-tt = FPAm-tt ) FPAbtt = FPAm-tt PA(m+1)-T = PAm-T ) PAbT = PAm-T FPA(m+1)-T = FPAm-T ) FPAbT = FPAm-T where PAm-tt is the set of languages computable by polynomial-time Turing machines that make m nonadaptiv...

We reported previously that protein associated with Myc (PAM) interacts with the C2 domain of type V adenylyl cyclase (ACV-C2) and that purified PAM is a potent inhibitor of Galphas-stimulated ACV activity (J Biol Chem 276:47583-47589, 2001). The present study was conducted to identify the region in PAM that inhibits ACV activity and to determine whether its binding with the ACV-C2 is necessary...

We propose a formal procedure-based agent model for plan recognition as an alternative to the declarative proposition-based agent model. Our formalism, called the Procedural Agent Model (PAM) allows us to describe procedural plans of agents in a concise and abstract way. Plan recognition uses PAM as a library of plan schemas and applies a graph-based pattern-matching algorithm to the observed e...