Le carcinome verruqueux est une variété de carcinome épidermoïde totalement différencié. Il se développe habituellement au niveau des régions oro-génitales. Il siège rarement au niveau cutané où il est désigné sous le terme d'épithélioma cunniculatum (E.C). R.M âgée de 41 ans avait depuis 4 mois une lésion bourgeonnante de la cuisse, à surface verruqueuse, arrondie, bien limitée, de 3 cm de dia...

La syphilis est une infection sexuellement transmissible due au Treponema palidum. Elle est en forte recrudescence en rapport avec la pandémie du VIH; caractérisée par son polymorphisme clinique, elle est appelée la grande simulatrice. La bénignité des formes précoces et la gravité des formes tardives soulignent l'intérêt du diagnostic et du traitement précoce. Son diagnostic est sérologique, s...

Paraneoplastic pemphigus (PNP) also called Autoimmune Multiorgan Syndrome (PAMS), is a rare but severe clinical variant of with high mortality rate. It clinically characterized by polymorphic muco-cutaneous and polyorgan involvement in association malignancies mostly lymphoproliferative origin. The diagnosis PNP/PAMS requires specific clinical, histological immunological criteria. In Bulgaria t...

BACKGROUND Previous clinical trials have not evaluated improvement in nail psoriasis as a primary end point. OBJECTIVE This phase 3 trial evaluated the safety and efficacy of adalimumab in patients with moderate-to-severe fingernail psoriasis and moderate-to-severe plaque psoriasis. METHODS Patients were randomized 1:1 to 40 mg adalimumab every other week or placebo. The primary efficacy en...

BACKGROUND Palmoplantar pustular psoriasis is often recalcitrant to therapy. Here we evaluated the therapeutic effect of alitretinoin in patients with recalcitrant palmoplantar pustular psoriasis and investigated subsequent immunopathological alterations. METHODS Seven patients with palmoplantar pustular psoriasis were treated with oral alitretinoin 30 mg once daily for 12 weeks. Efficacy was...

BACKGROUND General practitioners (GPs) are in best position to suspect dementia. Mini-Mental State Examination (MMSE) and Clock Drawing Test (CDT) are widely used. Additional neurological tests may increase the accuracy of diagnosis. We aimed to evaluate diagnostic ability to detect dementia with a Short Smell Test (SST) and Palmo-Mental Reflex (PMR) in patients whose MMSE and CDT are normal, b...

Sjögren-Larsson syndrome (SLS) is a recessively inherited disease with congenital ichthyosis, spastic diplegia or tetraplegia and mental retardation, caused by a deficiency of fatty aldehyde dehydrogenase. The aim of this study was to examine all 34 Swedish patients with SLS, emphasizing skin symptoms, dermatological treatment, and neurological symptoms (evaluated in some cases for more than 25...

OBJECTIVES Tumor necrosis factor alpha (TNF-α ) therapy has been implicated in the development of autoimmune diseases. Our aim was to describe three patients with spondyloarthropathies who responded to infliximab, a chimeric monoclonal antibody specific for TNF-α but developed new symptoms of spondyloarthropathies. In parallel, a review of the literature on psoriasis induced by TNF-α blockers w...