1. A method for isolating nuclei in quantity from mammalian tissues is described. 2. The rate of uptake of radioactive phosphorus by nuclei is found to be quite rapid. The phosphorus was shown not to be taken up by exchange. 3. Nuclei of tumors accumulate more radioactive phosphorus than normal liver nuclei. This was shown to be due to mitotic activity and not a form of metabolism peculiar to t...

The FLP protein that is encoded by the 2-microns plasmid of yeast Saccharomyces cerevisiae is a 45-kDa site-specific recombinase that belongs to the Int family of recombination proteins. FLP catalyzes a recombination event within the plasmid by binding specifically to each of three 13-base pair (bp) symmetry elements of the FLP recognition target (FRT). We have shown previously that partial pro...

BACKGROUND & OBJECTIVES The available serological techniques for the diagnosis of leptospirosis have less sensitivity during the early stage of the disease. Understanding of leptospiral proteins expressed during acute and convalescent phases of leptospirosis, would be help the develop of new serodiagnostic strategies. Therefore, the present study was carried out to identify (i) an antigen that ...

OBJECTIVE Cystic craniopharyngiomas are considered the most common intracranial nonglial tumor in children with the tendency for cyst formations. The aim of this study was to evaluate the effect of intracystic phosphorus 32 (P32) therapies on controlling the growth of the cystic component of craniopharyngioma. MATERIALS & METHODS This clinical study was conducted on 47 patients with cystic cr...

NACTIVATION of bacteria and bacteriophages by decay of incorporated radio‘active phosphorus (P”) has been reported by STENT and FUERST (1955), FUERST and STENT (1956), STRAUSS, VAHARU, FRICKEY and MATHESON (1956), TESSMAN, TESSMAN and STENT (1957), MCFALL, PARDEE and STENT (1958), and KAUDEWITZ, VIELMETTER and FRIEDRICH-FREKSA ( 1958). These authors have suggested that the P32 disintegrations w...

Sepsis is a major cause of morbidity and mortality in seriously ill patients and mitochondrial dysfunction is associated with poor outcomes in septic patients. Although interleukin-6 (IL-6) is a good prognostic marker for sepsis, the relationship between mitochondrial dysfunction and IL-6 remains poorly understood. We identified p32/C1QBP/HABP1 as a regulator of IL-6 production in response to l...