The pharmacological properties of any drug are related to their ability to interact with macromolecular blood components. The interaction of human serum albumin (HSA) and apotransferrin (ATf) with six RuII complexes containing ketoconazole (KTZ), which we have previously reported to be active against Leishmania major and Trypanosoma cruzi, has been investigated by monitoring the tryptophan fluo...

BACKGROUND A comparative analysis by using static headspace (HS) and steam distillation (SD) GC-MS of the volatile and the semi-volatile secondary metabolites from leaves of cultivated Majorana syriaca. METHODS The essential oils endogenous to cultivated thyme were isolated and identified by HS-GC-MS technology and compared to those from SD-GC-MS. RESULTS The HS-GC-MS results showed that th...

In the title complex, [RuSn(2)(C(10)H(14))Cl(6)(C(6)H(15)O(3)P)], the Ru-Sn bond lengths [2.5619 (3) and 2.5669 (3) Å] are about 0.3 Å shorter than the sum of the covalent Ru and Sn radii (1.46 + 1.39 = 2.85 Å), in line with other structurally characterized arene ruthenium trichlorido-stannyl derivatives. The Ru(II) atom is surrounded by a para-cymene, a triethylphosphite and two trichloridosta...

The title compound, [RuCl(2)(C(10)H(14))(C(6)H(6)FN)], a pseudo-octa-hedral d(6) complex, has the expected piano-stool geometry around the Ru(II) atom. The fluoro-aniline ring forms a dihedral angle of 19.3 (2)° with the p-cymene ring. In the crystal, two mol-ecules form an inversion dimer via a pair of N-H⋯Cl hydrogen bonds. Weak inter-molecular C-H⋯Cl inter-actions involving the p-cymene ring...

1,1 0-Ferrocene dicarboxylic acid pyridin-4-yl ester (1) is prepared from 1,1 0-ferrocene dicarbonyl chloride and 4-hydroxypyridine. This new bidentate ferrocenoyl ligand reacts with the monocationic complex [(g-p-cymene)2Ru2(l-OH)3] + to give the dicationic complex [(g-p-cymene)2Ru2(l-OH)2(1,1 0(NC5H4–OOC)2–Fc)] 2+ (2) (Fc: C5H4–Fe–C5H4), isolated as a tetrafluoroborate salt. The single-crysta...

Cationic tetranuclear arene ruthenium complexes of the general formula [Ru4(p-cymene)4(N N)2(dhnq)2] comprising rectangular structures are obtained in methanol from the reaction of the dinuclear arene ruthenium precursor [Ru2(p-cymene)2(dhnq)2Cl2] (dhnq = 5,8-dihydroxy-1,4-naphthoquinonato) with pyrazine or bipyridine linkers [N N = pyrazine, 1; 4,4 -bipyridine, 2; 1,2-bis(4-pyridyl)ethylene, 3...