In the study of the relationship between structure and biological activity in the neurohypophysial hormones, oxytocin and vasopressin, attention has recently been focused in this and other laboratories on the chemical functional groups. Aside from peptide linkages, these chemical functional groups in oxytocin consist of a primary amino, a phenolic hydroxyl, three carboxamide groups, and a disul...

The hypothalamic neuroendocrine system has extensive and bidirectional interactions with immune system. In parallel with the hypothalamic-pituitary-adrenal axis, the oxytocin-secreting system composed of hypothalamic oxytocin neurons and their associated neural tissues has also emerged as a major part of the neuroendocrine center that regulates immunologic activities of living organisms. This o...

s | 39 Abstract Oxytocin has been proposed as a potential treatment approach in drug addiction, but little is known about the effects of oxytocin in translationally relevant models of addiction or the neurobiological substrates of the actions of oxytocin. This presentation highlights the ability of oxytocin to reduce drug taking and drug seeking in a rat model of methamphetamine (meth) addictio...

role of labor induction has increased in the last decade due to the ‎early detection of fetal jeopardy. although very useful, oxytocin alone is not always successful for induction of ‎labor. in a randomized clinical ‎trial we compared vaginal dinoprostone plus oxytocin with oxytocin alone for ‎induction of labor in 91 ‎pregnant women at 40 weeks or greater gestation with bishop scores ≤ 4. fort...

Oxytocin, a neurohypophyseal hormone, has been traditionally considered essential for mammalian reproduction. In addition to uterine contractions during labor and milk ejection during nursing, oxytocin has been implicated in anterior pituitary function, paracrine effects in the testis and ovary and the neural control of maternal and sexual behaviors. To determine the essential role(s) of oxytoc...

s | 39 Abstract Oxytocin has been proposed as a potential treatment approach in drug addiction, but little is known about the effects of oxytocin in translationally relevant models of addiction or the neurobiological substrates of the actions of oxytocin. This presentation highlights the ability of oxytocin to reduce drug taking and drug seeking in a rat model of methamphetamine (meth) addictio...

BACKGROUND Blunted facial affect is a common negative symptom of schizophrenia. Additionally, assessing the trustworthiness of faces is a social cognitive ability that is impaired in schizophrenia. Currently available pharmacological agents are ineffective at improving either of these symptoms, despite their clinical significance. The hypothalamic neuropeptide oxytocin has multiple prosocial ef...

INTRODUCTION: Various studies indicate that decreased oxytocin is involved as a mechanism of delayed ejaculation induced by SSRIs. The aim of the present pilot study was to evaluate and compare sexual dysfunction and oxytocin levels in women being treated with either fluoxetine or citalopram. METHODS: Thirty-nine women with the diagnoses of major depressive disorder were enrolled in the study. ...

INTRODUCTION: Various studies indicate that decreased oxytocin is involved as a mechanism of delayed ejaculation induced by SSRIs. The aim of the present pilot study was to evaluate and compare sexual dysfunction and oxytocin levels in women being treated with either fluoxetine or citalopram. METHODS: Thirty-nine women with the diagnoses of major depressive disorder were enrolled in the study. ...