نتایج جستجو برای: oxypurinol

تعداد نتایج: 163  

Journal: :Circulation research 2015
Raul A Dulce Vera Mayo Erika B Rangel Wayne Balkan Joshua M Hare

RATIONALE Although nitric oxide (NO) signaling modulates cardiac function and excitation-contraction coupling, opposing results because of inconsistent experimental conditions, particularly with respect to temperature, confound the ability to elucidate NO signaling pathways. Here, we show that temperature significantly modulates NO effects. OBJECTIVE To test the hypothesis that temperature pr...

Journal: :Hypertension 1999
R P Brandes G Koddenberg W Gwinner D y Kim H J Kruse R Busse A Mügge

Superoxide anions (O2-) are supposedly involved in the pathogenesis of endothelial dysfunction. We investigated whether the enhanced formation of O2- is involved in the attenuation of endothelium-dependent relaxation induced by lipopolysaccharide (LPS). Rats were injected with LPS (10 mg/kg IP), the aorta was removed after 12 or 30 hours, and generation of O2-, H2O2, and ONOO- was measured usin...

2018
Roy Fleischmann Peter Winkle Jeffrey N Miner Xiaohong Yan Liz Hicks Shakti Valdez Jesse Hall Sha Liu Zancong Shen Michael Gillen Martha Hernandez-Illas

Objectives Verinurad (RDEA3170) is a high affinity, selective uric acid transporter (URAT1) inhibitor indevelopment for treating gout and asymptomatic hyperuricaemia. This phase IIa study evaluated the pharmacodynamics, pharmacokinetics and safety of verinurad combined with allopurinol versus allopurinol alone in adults with gout. Methods Forty-one subjects were randomised into two cohorts of...

Journal: :American journal of physiology. Heart and circulatory physiology 2003
J Scott McNally Michael E Davis Don P Giddens Aniket Saha Jinah Hwang Sergey Dikalov Hanjoong Jo David G Harrison

Oscillatory shear stress occurs at sites of the circulation that are vulnerable to atherosclerosis. Because oxidative stress contributes to atherosclerosis, we sought to determine whether oscillatory shear stress increases endothelial production of reactive oxygen species and to define the enzymes responsible for this phenomenon. Bovine aortic endothelial cells were exposed to static, laminar (...

Journal: :American journal of physiology. Heart and circulatory physiology 2006
Anna V Naumova Vadappuram P Chacko Ronald Ouwerkerk Linda Stull Eduardo Marbán Robert G Weiss

After myocardial infarction, ventricular geometry and function, as well as energy metabolism, change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves mechanoenergetic coupling by improving contractile performance relative to a reduced energetic demand. However, the metabolic and contractile effects of XO inhibitors (XOIs) have not been characterized in failin...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2013
Yiling Fu Yan Lu Eddie Y Liu Xiaolong Zhu Gouri J Mahajan Deyin Lu Richard J Roman Ruisheng Liu

Males have higher prevalence of hypertension and renal injury than females, which may be attributed in part to androgen-mediated effects on renal hemodynamics. Tubuloglomerular feedback (TGF) is an important mechanism in control of renal microcirculation. The present study examines the role of testosterone in the regulation of TGF responses. TGF was measured by micropuncture (change of stop-flo...

Journal: :Clinical chemistry 1987
J L Potter A A Silvidi

An 11-year-old boy who presented in acute renal failure with significant increases of uric acid and phosphorus in his serum was discovered to have acute lymphoblastic leukemia. Five years later, he had a second and similar episode of acute renal failure, which was responsive to hemodialysis. After three months of daily therapy with allopurinol, a third and final episode of renal failure was unr...

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