Myoglobin (Mb) belongs to the family of vertebrate oxygen-binding haem proteins and is predominantly expressed in cardiac and red skeletal muscles that rely on aerobic metabolism to perform sustained work. Additional members of this protein family are of course haemoglobin, the red dye of blood, and the more recently discovered proteins neuroglobin and cytoglobin. Owing to the notoriously low s...

Since their introduction in 1985, oxygen concentrators have only been recommended when domiciliary oxygen is used for over 8 h day-1. Subsequent changes in the prices of oxygen merit a reappraisal of the prescribing of concentrators and cylinders when oxygen is used for less than 8 h day-1. Twenty-six patients in two health districts who used oxygen for less than 8 h day-1 completed a crossover...

1. Disciplina de Pneumologia, Universidade Federal de São Paulo, São Paulo (SP) Brasil. Tissues obtain energy primarily from oxygen. Adequate oxygen levels in the inhaled air and a preserved ventilation/ perfusion ratio (V • /Q) are the major determinants of oxygen supply to the blood. However, peripheral supply depends on effective oxygen transport to the tissue mitochondria, a critical task t...

There are circumstances when the oxygen supply to an anaesthetic apparatus can fail. If this is not noticed immediately, the patient becomes anoxic. Many of the oxygen failure warning devices available at the present time only give a visual or audible signal of the failure and they rely on a second gas supply (usually nitrous oxide) and/or batteries for their operation (Falkner Hill, 1956; Hosp...

Voltage-dependent potassium channels (Kv channels) are important determinants of brain electrical activity. Hypoxia may be an important modifier, because several voltage-gated K+ channels are reversibly blocked by acute hypoxia and are thought to act as oxygen sensors. Here we show, using the anoxia-tolerant turtle brain (Trachemys scripta) as a model, that brain Kv1 channel transcription is re...

Structural and functional integrity of organ function profoundly depends on a regular oxygen and glucose supply. Any disturbance of this supply becomes life threatening and may result in severe loss of organ function. Particular reductions in oxygen availability (hypoxia) caused by respiratory or blood circulation irregularities cannot be tolerated for longer periods due to an insufficient ener...

[1] Recent analysis of sedimentary dN records over the last 200,000 years has shown an expansion of water column denitrification zones during warmer periods and a shrinkage of these oxygen-poor regions during glacial periods. Two different mechanisms could be responsible for driving the changes in the denitrification records: variations in local productivity leading to a change in remineralizat...

Coenzyme Q(10) (CoQ(10)) productions from Rhizobium radiobacter T6102 were monitored under various oxygen supply conditions by controlling the agitation speeds, aeration rates, and dissolved oxygen levels. As the results, the CoQ(10) production was enhanced by limited oxygen supply. To investigate whether the CoQ(10) production is associated with its physiological functions of electron carrier ...

Langendorff-perfused hearts and working hearts are established isolated heart preparation techniques that are advantageous for studying cardiac physiology and function, especially when fluorescence imaging is a key component. However, oxygen and energy requirements vary widely between isolated heart preparations. When energy supply and demand are not in harmony, such as when oxygen is not adequ...