Betulin (BT) has been identified to exhibit potential benefits for treating hepatocellular carcinoma (HCC). The results of the present study demonstrated that a new semisynthetic derivative of BT, 3,28-di-(2-nitroxy-acetyl)-oxy-BT, may effectively decrease the viability of Huh7 cells. Mechanistic studies revealed that 3,28-di-(2-nitroxy-acetyl)-oxy-BT inhibited the transition between G2 and M p...

Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a wide range of neurotransmitter and neuromodulator activities. Additionally, through the neurohypophysis, oxy is secreted into the systemic circulation to act as a hormone, thereby influencing several body functions. O...

In the title compound, C(18)H(19)Cl(3)O(2), which is the 4-eth-oxy-phenyl analogue of the insecticidally active 4-meth-oxy-phenyl compound meth-oxy-chlor, the dihedral angle between the two benzene rings is 60.38 (13)°. An intra-molecular aromatic C-H⋯Cl inter-action is present.

The dinuclear title complex, [Co(2)(C(15)H(8)O(7))(2)(H(2)O)(6)], lies across an inversion center. The unique Co(II) ion is coordinated in a slightly distorted octa-hedral coordination geometry by two O atoms from a chelating 4-(carb-oxy-phen-oxy)phthalate ligand, three water O atoms and a further O atom from a bridging carboxyl-ate group of a symmetry-related 4-(carb-oxy-phen-oxy)phthalate lig...

Two beta-lactamase gene regions were characterized by DNA sequencing in eight clinical isolates of Klebsiella oxytoca. The blaOXY-2a region encoded a beta-lactamase nearly identical to OXY-2 (one amino acid residue substituted) and conferred aztreonam and cefuroxime resistance on the K. oxytoca isolates. Overproduction of OXY-2a was caused by a G-to-A substitution of the fifth nucleotide in the...

In the title compound, C(19)H(18)ClN(3)O(3), the r.m.s. deviation through the 23 non-H and non-meth-oxy atoms is 0.088 Å, indicating a planar mol-ecule with the exception of the meth-oxy groups. One meth-oxy group, surrounded on either side by the other meth-oxy groups, is almost normal to the benzene ring to which it is connected [C-O-C(ar)-C(ar) torsion angle = 81.64 (15)°]. In the crystal, N...

Oxyresveratrol (OXY) is a small molecule phytochemical which has been reported to have important biological function. The aim of this study was elucidate the gene expression and pathways altered in MCF-7, breast cancer cells following exposure OXY. cytotoxicity different cell lines screened using MTT assay then whole elucidated microarray. selected were also validated by quantitative PCR analys...

It is supposed that Glu, and OXY are synthesized and stored in the same structure and parts of the brain. Both Glu and its receptors are located in different neurosecretory nuclei of the hypothalamus which are associated with neuroendocrine function. It have been demonstrated the presence of Glu in nucleus Paraventricularis (PVN), nucleus Ventro-Medianus (VMN), nucleus arcuatus, nucleus Supraop...

We examined the changes in regional cerebral blood volume (rCBV) around visual cortex using Near Infrared Spectroscopy (NIRS) when observers attended to visual scenes. The oxygenated and deoxygenated hemoglobin (Oxy-Hb and Deoxy-Hb) concentration changes at occipital lobe were monitored during a dual task. Observers were asked to name a digit superimposed on a scenery picture, while in parallel...

In the title compound, C21H21NO5, obtained from a Morita-Baylis-Hillman adduct, the hydrogenated five-membered ring adopts a shallow envelope conformation, with the C atom bearing the carb-oxy-lic acid substituent deviating by 0.237 (1) Å from the mean plane of the other four atoms (r.m.s. deviation = 0.007 Å). The dihedral angle between the fused ring system (all atoms; r.m.s. deviation = 0.05...