Oxidative stress has been known to be involved in pathogenesis of dry eye disease. However, few studies have comprehensively investigated the relationship between hyperosmolarity and oxidative damage in human ocular surface. This study was to explore whether and how hyperosmolarity induces oxidative stress markers in primary human corneal epithelial cells (HCECs). Primary HCECs were established...

BACKGROUND There is increasing evidence for the presence of oxidative stress and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding the effects of vitamin C supplementation on oxidative stress and inflammation markers in such patients. METHODS We ran a prospective, randomized, open-label trial to assess the effects of oral vitamin C supplementation (250 ...

Chronic glaucoma is a multifactorial disease among which oxidative stress may play a major pathophysiological role. We conducted a systematic review and meta-analysis to evaluate the levels of oxidative and antioxidative stress markers in chronic glaucoma compared with a control group. The PubMed, Cochrane Library, Embase and Science Direct databases were searched for studies reporting oxidativ...

objective: the purpose of this work was to compare dna damage, acetylcholinesterase (ache) activity, inflammatory markers and clinical symptoms in farmers exposed to organophosphorus pesticides to individuals that had no pesticide exposure. materials and methods: we conducted a cross-sectional survey with a total of 134 people. the subject group consisted of 67 farmers who were exposed to organ...

BACKGROUND/AIM The novel static (sORP) and capacity (cORP) oxidation-reduction potential markers were examined for assessing oxidative stress in plasma of patients with sepsis. Moreover, the possible effect of obesity-induced oxidative stress on patients with sepsis was investigated. MATERIALS AND METHODS sORP and cORP markers, as well as the conventional oxidative stress biomarkers total ant...

Salivary oxidative stress markers represent a promising tool for monitoring of oral diseases. Saliva can often be contaminated by blood, especially in patients with periodontitis. The aim of our study was to examine the impact of blood contamination on the measurement of salivary oxidative stress markers. Saliva samples were collected from 10 healthy volunteers and were artificially contaminate...

Saliva is an interesting alternative diagnostic body fluid with several specific advantages over blood. These include non-invasive and easy collection and related possibility to do repeated sampling. One of the obstacles that hinders the wider use of saliva for diagnosis and monitoring of systemic diseases is its composition, which is affected by local oral status. However, this issue makes sal...

trenuous physical exercise is thought to stimulate increased production of reactive oxygen species (ROS), as demonstrated by elevated markers of oxidative stress in the skeletal muscle, blood, and urine of athletes. Antioxidant supplementation has been shown to reduce levels of such markers, and as such, holds promise for limiting exercise-induced oxidative damage, reducing the rate of muscle f...