BACKGROUND Portacaval shunting in rats produces a reduction of hepatic oxidant scavenging ability. Since this imbalance in hepatic oxidant/antioxidant homeostasis could coexist with systemic changes of oxidant stress/antioxidant status, plasma oxidants and antioxidant redox status in plasma of portacaval shunted-rats were determined. RESULTS Male Wistar male: Control (n = 11) and with portaca...

Assessment of oxidative stress markers was perfomed in prostate cancer (PCa) patients subjected to high-dose brachytherapy (HDR) with external beam radiotherapy (EBRT). Sixty men with PCa were subjected to combined two-fraction treatment with HDR (tot. 20 Gy) and EBRT (46 Gy). Blood samples were taken before treatment, immediately afterwards, after 1.5-3 months, and approx. 2 years. Control gro...

Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb), which affects approximately a million people worldwide. It characterized by single nucleotide substitution in ?-globin gene, leading to production abnormal sickle (HbS) with multi-system consequences. HbS polymerization primary event SCD. Repeated and depolymerization Hb causes oxidative stress that plays key r...

OBJECTIVE Childhood obesity is an important cause of cardiovascular risk with chronic inflammation. Oxidative stress may contribute to the pathogenesis of obesity-related cardiovascular pathologies. We aimed to evaluate thiol/disulphide homeostasis as a novel and sensitive marker of oxidative stress and to evaluate its relationship with some inflammatory and cardiovascular markers in obese chil...

BACKGROUND & OBJECTIVES We evaluated pro- and anti-oxidant disturbances in sepsis and non-sepsis burn patients with systemic inflammatory response syndrome (SIRS). Adhesion molecules and inflammation markers on leukocytes were also analyzed. We hypothesized that oxidative stress and leukocyte activation markers can lead to the severity of sepsis. METHODS In 28 severe sepsis and 27 acute burn ...

background: to attain whether the effects of low and high doses of estrogen progesterone luteinizing hormone (lh) and follicle stimulating hormone (fsh) in acute and chronic administration were related to oxidant and antioxidant parameters in rat uterine tissue as well as cyclooxygenase-1 (cox-1) activity. materials and methods: acute and chronic administration of estrogen (1 and 5 mg/ kg) prog...

conclusions beta-alanine supplementation has limited antioxidant effect during the repeated wts. background carnosine is a dipeptide formed from the β-alanine and histidine amino acids and found in mainly in the brain and muscle, especially fast twitch muscle. carnosine and creatine has an antioxidant effect and carnosine accounts for about 10% of the muscle's ability to buffer the h+ ions prod...

introduction: the molecular mechanisms involved in pathogenesis of esophageal cancer have been the main concern of several studies. in this study, we aimed to investigate the changes of serum prooxidant-antioxidant balance (pab) value as a redox index, as well as serum c-reactive protein (crp) compared to healthy control group. materials and methods: in a cross-sectional study, blood samples we...