OBJECTIVE To analyze seizure control and treatment in pregnant women with epilepsy. METHODS Seizure control and treatment were recorded prospectively in 1,956 pregnancies of 1,882 women with epilepsy participating in EURAP, an international antiepileptic drugs (AEDs) and pregnancy registry. RESULTS Of all cases, 58.3% were seizure-free throughout pregnancy. Occurrence of any seizures was as...

Basic haematologic parameters and serum gamma-glutamyl-transferase (GGT) activity were evaluated in a five-year prospective follow-up study of 25 patients with newly diagnosed epilepsy starting treatment with carbamazepine. In addition, we evaluated the effects of replacing carbamazepine by oxcarbazepine on these parameters, erythrocyte folate concentrations and serum vitamin B12 levels in 12 m...

OBJECTIVE To compare the effectiveness of antiepileptic drugs (AEDs) for use in older adults with epilepsy. DESIGN Retrospective review. SETTING Columbia Comprehensive Epilepsy Center, New York, New York. PATIENTS Four hundred seventeen outpatients 55 years and older newly taking any of the 10 most commonly prescribed AEDs between 2000 and 2005. MAIN OUTCOME MEASURE The percentage of pa...

BACKGROUND In Belgium, new and costly antiepileptic drugs (AEDs) are only reimbursed as second-line treatment, after documented treatment with conventional and cheaper AEDs has failed. The objective of this study was to describe the treatment of epilepsy in Belgium and to analyze the impact of the reimbursement restrictions on the choice of AEDs. METHODS Between May and June 2003, a sample of...

A 38-year old male patient with pharmacoresistant bilateral temporal-lobe epilepsy was referred to our department for adjustment of antiepileptic-drug dosage with continuous VideoEEG monitoring. In 2013, bilateral deep brain electrodes were implanted for chronic stimulation in both anterior thalamic nuclei. After implantation, the patient remained seizure free of generalized tonic-clonic seizur...

In a retrospective study we assessed the outcome of oxcarbazepine (OXC) monotherapy in a naturalistic setting. We identified all adult patients who had been treated with OXC at a single neurological outpatient center. A total of 175 patients were identified, 97 of them used OXC as their first AED (Group I), and 78 as second monotherapy (Group II), after failure of a previous AED. The 1-year ret...

Investigators from Child Neurology and Pediatrics, University of Texas Health Science Center, Houston, report extrapyramidal symptoms in a 13-year-old boy with a psychiatric history of schizophrenia, bipolar disorder, ADHD, and autism, responsive to combination risperidone, oxcarbazepine, and MPH.

Eslicarbazepine acetate is an advanced antiseizure medication that improvement upon carbamazepine and oxcarbazepine. This novel regulates voltage-gated sodium channels provides fewer adverse effects better tolerability. Herein, we present the characteristics, pharmacokinetics, drug interactions of eslicarbazepine based on research has been conducted to date. Key words: acetate; Pharmacokinetics...