The fruitfly Drosophila melanogaster is increasingly used as a model organism for studying acute hypoxia tolerance and for studying aging, but the interactions between these two factors are not well known. Here we show that hypoxia tolerance degrades with age in post-hypoxic recovery of whole-body movement, heart rate and ATP content. We previously used (1)H NMR metabolomics and a constraint-ba...

We briefly review the well-known risks, weaknesses and limitations of spreadsheets and then introduce some more. We review and slightly extend our previous work on the importance and criticality of spreadsheets in the City of London, introducing the notions of ubiquity, centrality, legality and contagion. We identify the sector of the financial market that we believed in 2005 to be highly depen...

This paper reviews the characteristics of clinical perfectionism and proposes a new definition of the phenomenon. It is suggested that the defining feature of clinically significant perfectionism is the overdependence of self-evaluation on the determined pursuit (and achievement) of self-imposed personally demanding standards of performance in at least one salient domain, despite the occurrence...

The Mumford-Shah functional has had a major impact on a variety of image analysis problems, including image segmentation and filtering, and, despite being introduced over two decades ago, it is still in widespread use. Present day optimization of the Mumford-Shah functional is predominated by active contour methods. Until recently, these formulations necessitated optimization of the contour by ...

This article criticizes the predominant use of fear appeals in social marketing. Laboratory studies, which have been the basis for most of the research on fear appeals and which generally suggest that high fear works, have limitations that include forced exposure, short-term measurement, and an overdependence on student samples. Although, unfortunately, field research evaluations of fear appeal...

Abstract The aim of any early warning systems is to provide warning to people of an impending natural hazard so that those vulnerable are aware of the potential impact of the natural processes in order to respond appropriately and minimise damage. This paper looks at variables affecting the implementation of flood hazard early warning systems in a flood prone area of Zimbabwe. Documenting the e...

We developed an empirical Bayes procedure to estimate genetic distances between populations using allele frequencies. This procedure makes it possible to describe the skewness of the genetic distance while taking full account of the uncertainty of the sample allele frequencies. Dirichlet priors of the allele frequencies are specified, and the posterior distributions of the various composite par...

OBJECTIVE To identify types of clinical unintended adverse consequences resulting from computerized provider order entry (CPOE) implementation. DESIGN An expert panel provided initial examples of adverse unintended consequences of CPOE. The authors, using qualitative methods, gathered and analyzed additional examples from five successful CPOE sites. METHODS Using a card sort method, the aut...

The new coronavirus or COVID-19 that spread from China in early 2020 has become a global pandemic, infecting and killing millions worldwide. Besides the human cost, economic social costs of are turning out to be enormous most societies on planet. lingering disease raised concerns related various strategic issues likely affect order per se profoundly. This article discusses possibility worldwide...

The emerging environmental consequences of overdependence on fossil fuels have pushed many countries to invest in clean and renewable sources power. Countries like Iran where these can be found abundance take advantage this potential reduce their dependence fuels. This study investigated the feasibility standalone use a hybrid energy system (HRES) power buildings Bostegan village Hormozgan prov...