Various ovarian cell types including granulosa cells and ovarian surface epithelial cells express the progesterone (P4) binding protein, progesterone receptor membrane component-1 (PGRMC1). PGRMC1 is also expressed in ovarian tumors. PGRMC1 plays an essential role in promoting the survival of both normal and cancerous ovarian cell in vitro. Given the clinical significance of factors that regula...

The National Toxicology Program (NTP) classification system for rat and mouse ovarian tumors is presented. The classification system is based on previous classification systems and on a review of all the primary ovarian tumors from the archives of the National Cancer Institute (NCI) and NTP Carcinogenesis Testing Programs. The relative frequency and principal diagnostic features of 204 ovarian ...

BACKGROUND Epithelial ovarian carcinoma is a significant cause of cancer mortality in women worldwide and in the United States. Epithelial ovarian cancer comprises several histological subtypes, each with distinct clinical and molecular characteristics. The natural history of this heterogeneous disease, including the cell types of origin, is poorly understood. This study applied recently develo...

OBJECTIVE Currently, there is not a fully characterized model for human ovarian cancer; however, 2- to 4-year-old laying hens spontaneously develop ovarian tumors. CA125 expression is a hallmark of ovarian cancer in women. The major objective of this study was to characterize the in vitro growth of avian ovarian tumor cells, and CA125 expression in avian ovarian tumors. METHODS Immunohistoche...

Few studies have evaluated Hedgehog (Hh) signaling pathway activation in different types of ovarian tumors including benign, borderline and malignant ovarian tumors. The present study investigated the expression of Hh signaling pathway components (SHH, SMO, PTCH, and GLI1) in 193 ovarian epithelial tumor specimens (including 147 malignant epithelial ovarian cancers, 30 borderline ovarian tumors...

Background: Ovarian neoplasm is a type of cancer caused by uncontrolled growth and division cells within the ovary. It common gynecological that affects wide range ages can have various clinical, morphological, histological features. This study aimed to examine relationship between clinical presentation pattern ovarian neoplasm. Methods: cross-sectional conducted among 45 patients admitted depa...

One of the main health issues facing general practitioners in and gynecologists particular is ovarian tumors. Ovarian cancer second most prevalent malignancy female reproductive system fifth leading cause cancer-related death women. The majority instances are discovered when disease has already progressed even though early neoplasms benign which emphasizes importance detection.  &nbsp...

Incidence of ovarian malignancy in children and adolescents is 1 to 1.5% with non-epithelial tumors being the most common type. Ovarian mucinous commonly seen third sixth decade, are rarely adolescents. Timely diagnosis management important save patient’s life fertility. We presenting an interesting case a 16-year-old girl atypical borderline tumor.

Borderline ovarian tumors represent about 10% of all epithelial ovarian cancers, but in contrast to epithelial ovarian cancers, they constitute a group of tumors with a much better prognosis. An assessment of clinical presentation, physical examination, radiological and biochemical findings is necessary to tailor management strategies for patients with ovarian tumors. The article, which is base...

The aim of this current study was to investigate the expression of the tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) in human malignant ovarian tumors, and test TWEAK's potential role on tumor progression in cell models in-vitro. Using immunohistochemistry (IHC), we found that TWEAK and its receptor Fn14 were exp...