INTRODUCTION Preliminary data suggested that non-invasive methods could be useful to assess presence of oesophageal varices (OV) in liver cirrhosis. The primary objectives were to investigate non-invasive markers for diagnosing and grading OV in patients with primary biliary cirrhosis. MATERIAL AND METHODS This study included a total of 106 consecutive treatment-naive patients with primary bi...

Circadian rhythms in mammals are regulated not only globally by the master clock in the suprachiasmatic nucleus (SCN), but also locally by widely distributed populations of clock cells in the brain and periphery that control tissue-specific rhythmic outputs. Here we show that the oval nucleus of the bed nucleus of the stria terminalis (BNST-OV) exhibits a robust circadian rhythm in expression o...

Background: Cancer antigen CA125 is known as a valuable marker for the management of ovarian cancer. Methods: The analytical and clinical performance of the Access OV Monitor Immunoassay System (Beckman Coulter) was evaluated at five different European sites and compared with a reference system, defined as CA125 on the Elecsys System (Roche Diagnostics). Results: Total imprecision (%CV) of the ...

AIMS To analyse the distribution of OV-TL 3 and MOv18 in normal ovarian tissue to determine which antibody is most suitable for (radio)immunotherapy of ovarian carcinoma. METHODS The distribution of OV-TL 3 and MOv18 was determined using immunohistochemistry and flow cytometry. RESULTS Epithelial and other cells in many tissues, and leucocytes in peripheral blood, bone marrow and spleen sta...

Oncolytic virotherapy (OV) is an emerging class of immunotherapeutic drugs. Their mechanism action two-fold: direct cell lysis and unmasking the cancer through immunogenic death, which allows immune system to recognize eradicate tumours. Breast most common in women challenging treat with immunotherapy modalities because it classically immunogenically “cold” tumour type. This provides attractive...

Oncolytic viral therapy is under evaluation for toxicity and efficacy in clinical trials relating to several different tumors. We report a significant increase in the angiogenic index of oncolytic virus (OV)-treated glioma-matrigel implants (2.83-fold, P < 0.02). In a rat intracranial glioma model, large tumors from OV-treated animals were significantly more angiogenic than the phosphate-buffer...

To increase public health awareness for prevention of opisthorchiasis caused by eating raw freshwater fish, the distribution and abundance of Opisthorchis viverrini metacercariae (OV MC) was investigated in freshwater fish obtained from 20 provinces in northeastern Thailand between April 2011 and February 2012. A cross-sectional survey was conducted on 12,890 fish consisting of 13 species rando...

Background—The aim of this study was to validate exhaled nitric oxide (eNO) values obtained with an alternative oV line, single breath, low flow balloon sampling method against on line sampling according to ERS and ATS guidelines in children who could perform both methods. Methods—One hundred and twenty seven white children of median age 14.1 years, all pupils of a secondary school, participate...