INTRODUCTION Loss of bone due to disuse osteopenia remains an unsolved and debilitating problem. While some current therapies rely on weightbearing activities to promote new bone growth, disuse osteopenia often occurs in situations in which weight bearing or mechanical loading of bone is impractical, e.g. in bedridden or mobility limited individuals or in microgravity conditions. Hence, new the...

Background: Decrease in bone mineral density (BMD) is common individuals infected with human immune deficiency virus (HIV) and the rate of osteopenia, osteoporosis fracture risk are higher than gene-ral population. In our study, we aimed to evaluate frequency osteoporosis/osteopenia according results dual-energy X-ray absorptiometry (DXA) examination associated factors also 25 (OH) vitamin D.Ma...

abstract background: very low birth weight infants ( <1500 g) frequently require blood transfusions because of repeated blood sampling accompanied by anemia of prematurity. methods: in an attempt to identify the effect of human recombinant erythropoietin to decrease the requirement for blood transfusions, erythropoietin was administered to 24 pre term infants less than 1500 g prospectively from...

BACKGROUND Although bone mineral density (BMD) testing to screen for osteoporosis (BMD T score, -2.50 or lower) is recommended for women 65 years of age or older, there are few data to guide decisions about the interval between BMD tests. METHODS We studied 4957 women, 67 years of age or older, with normal BMD (T score at the femoral neck and total hip, -1.00 or higher) or osteopenia (T score...

It is not widely appreciated how deleterious prolonged periods of non-weight-bearing are to skeletal integrity. Rates of decline in humans exposed to prolonged spaceflight, for example, are about 10-fold greater than those observed in postmenopausal women and are associated with a significant loss of bone strength. New data on the efficacy of muscle contraction independent of weight bearing in ...

Objectives Multiple studies have documented the presence of systemic osteopenia in AIS. Osteopenia was associated with severe curves and was reported to be one of the significant prognostic factors for curve progression in AIS. This study aimed to evaluate bone quality and bone strength parameters including rod-plate configuration and finite element analysis (FEA) with in vivo HighResolution Pe...

Therapeutic effects of mesenchymal stem cell (MSC) infusion have been revealed in various human disorders, but impacts of diseased micro-environments are only beginning to be noticed. Donor diabetic hyperglycemia is reported to impair therapeutic efficacy of stem cells. However, whether recipient diabetic condition also affects MSC-mediated therapy is unknown. We and others have previously show...

Genetic factors have an important role in the incidence of osteopenia in thalassemia patients. The purpose of this study was to investigate the effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ (PPARγ) gene on bone mineral density (BMD) and subsequently, the rate of osteopenia in β-thalassemia major (β-TM) patients. Blood samples were obtained from 156 β-TM...