Nontraumatic osteonecrosis continues to be a challenging problem causing debilitating major joint diseases. The etiology is multifactorial, but steroid- and alcohol-induced osteonecrosis contribute to more than two thirds of all cases with genetic risk factors playing an important role in many other cases, especially when they contribute to hypercoagulable states. While the exact mechanisms rem...

Case presentations and current literature will be presented. April 21, 2010 7:30-8:20 AM Meniscal Transplantation LT Leah Brown, M.D., Navy Resident Department of Orthopaedic Surgery, NMCSD Abstract Case presentations and current literature will be presented.Case presentations and current literature will be presented. April 28, 2010 7:30-8:20 AM Depression Awareness and Fatigue Robert C. Searle...

The present study presents results from a linkage and mutation screening analysis aiming to identify the causative gene of femoral head necrosis, also known as osteonecrosis of femoral head (ONFH), in a Chinese pedigree. We collected clinical data on the osteonecrosis pedigree, and extracted blood and genomic DNA from the family members. Polymerase chain reaction (PCR) and direct sequencing all...

New cases of osteonecrosis of the femoral head in the United States number between 10,000 and 20,000 per year. This disease usually affects patients in their late 30s and early 40s. Although a number of authors have related specific risk factors to this disease, its etiology, pathogenesis, and treatment remain a source of considerable controversy. This disorder has been associated with corticos...

This article presents the history and development of as well as the results from the various techniques of vascularized bone grafting for the treatment of osteonecrosis (ON) of the femoral head. The authors have treated more than 2600 patients who had femoral head ON, using a vascularized fibular graft by way of an intraosseous approach. The results from this vast experience are summarized and ...

Posttraumatic osteonecrosis of the femoral head (ONFH) is the most serious complication after fracture dislocation of the femoral head. The rate of this complication was reported to range from 1.7% to 40%. Although the development of posttraumatic osteonecrosis normally occurs within 2 years of injury, there are some reports of the late development ONFH. The authors encountered a case of posttr...

Osteonecrosis or avascular necrosis (AVN) is a pathologic process that results from a critical decrease of blood supply to the bone and elevated intraosseous pressure [1]. While the pathogenic process is not clear, it is believed that osteonecrosis is the final common pathway of traumatic and non-traumatic insults and that it impairs blood circulation to the femoral head. Subsequently, interrup...

Introduction In adults, the greatest portion of the blood supply to the femoral head is derived from extraosseous vessels on the posterior lateral surface of the femoral neck with the main supply coming from a branch of the medial circumflex artery(Fig 1). When performing intra-articular procedures in non-arthritic hips, surgeons advocate surgical approaches and techniques to avoid damage to th...

BACKGROUND Femoral head osteonecrosis is frequently observed in patients treated with excessive corticosteroids. The objective of the current study was to establish a rat model to investigate the disruption of immune response in steroid-induced femoral head osteonecrosis via Toll-like receptor 4 (TLR4) signaling pathway. METHODS Male SD rats were divided into the treatment group (group A) and...

OBJECTIVE To compare the occurrence of thrombophilic disorders in patients with idiopathic osteonecrosis of the femoral head and patients with secondary osteonecrosis of the femoral head. METHODS Twenty-four consecutive patients were enrolled, with eight of them presenting idiopathic osteonecrosis and 16 presenting secondary osteonecrosis. The tests for detection of thrombophilic disorders we...