HLA-A, B and alpha 1-antitrypsin phenotypes were studied in 90 unrelated patients with established nodal generalised osteoarthritis (OA). Compared with standard reference populations, independently increased frequency of the HLA-A1B8 and MZ alpha 1-antitrypsin phenotypes were observed (27% v 11.5%, relative risk 2.79, and 12% v 3.6%, relative risk 3.73 respectively). These associations related ...

Background: Proximal tibial fractures in elderly patients with osteoporosis or knee osteoarthritis (OA) are challengingcases. In the current study, we present our experience with uncommon acute primary total knee arthroplasty (PTKA)in this patient population.Methods: PTKAs were performed following proximal tibial fractures in 30 consecutive patients over 60 years of agewith osteoporosis or knee...

management of first shoulder dislocation following reduction remains controversial. the two main options are immobilisation and arthroscopic stabilisation. the aim of this article is to highlight some of the issues that influence decision making when discussing management options with these patients, including natural history of the first time dislocation, outcomes of surgery and non-operative ...

OBJECTIVE Increased expression of tumor necrosis factor a (TNF-α) has emerged as an important inflammatory factor in osteoarthritis (OA) and other joint diseases. The study was performed to investigate whether the expression of TNF-α in human chondrocytes was regulated by miRNAs. METHODS MiRNA-130a and TNF-α expression in cartilage specimens was examined in patients with knee osteoarthritis, ...

This study is designed to determine whether the outermost layer of articular cartilage deficient in Osteoarthritis (OA). Phospholipids present healthy and osteoarthritis (OA) synovial fluid show significant differences their concentration. While examining surface properties OA joints, we found that PLs molecules cannot support lubrication, increased friction was observed. Our lubrication mechan...

OBJECTIVES To compare the prevalence of osteoarthritis (OA) of the hip, tibiofemoral and patellofemoral joints in a skeletal population. METHODS A total of 785 adult English skeletons (695 Saxon or Mediaeval origin) were examined for OA using established criteria. RESULTS Twenty nine skeletons had hip OA, compared with 14 with patellofemoral joint OA, and only four tibiofemoral joint OA. ...

BACKGROUND Osteoarthritis (OA) is a chronic degenerative joint disease that is a clinically and economically important disease. The increased prevalence of OA with aging, coupled to the demographics of aging populations, make OA a high priority health care problem. Viscosupplementation (VS) is a well-established treatment option in knee OA that is included in the professional guidelines for tre...

OBJECTIVE To evaluate associations between severity of knee osteoarthritis (OA) on magnetic resonance imaging (MRI) and treatment outcomes in knee OA patients treated with exercise therapy in an exploratory study. METHODS Ninety-five participants with knee OA in a 12-week exercise program had obtained 3.0T MRI scans of the knee joint prior to treatment. MRI data were systematically assessed f...

Osteoarthritis is a degenerative joint disorder characterized by breakdown of articular cartilage. Degradation of aggrecan, which together with type II collagen provides cartilage with its unique characteristics of compressibility and elasticity, is an early and sustained feature of osteoarthritis. The present work was set up to identify the enzyme(s) responsible for aggrecan breakdown in osteo...

BACKGROUND AND PURPOSE Pain sensitization may be one of the reasons for persistent pain after technically successful joint replacement. We analyzed how pain sensitization, as measured by quantitative sensory testing, relates preoperatively to joint function in patients with osteoarthritis (OA) scheduled for joint replacement. PATIENTS AND METHODS We included 50 patients with knee OA and 49 wi...