Because the microenvironment that supports hematopoietic stem cell (HSC) proliferation and differentiation is not fully understood, we adapted a heterotopic bone formation model as a new approach for studying the HSC microenvironment in vivo. Endogenous HSCs homed to tissue-engineered ossicles and individually sorted HSCs from ossicles were able to reconstitute lethally irradiated mice. To furt...

BACKGROUND The stapes, an ossicle found within the middle ear, is involved in transmitting sound waves to the inner ear by means of the oval window. There are several developmental problems associated with this ossicle and the oval window, which cause hearing loss. The developmental origin of these tissues has not been fully elucidated. RESULTS Using transgenic reporter mice, we have shown th...

Introduction Inflammation causes squamous epithelial transformation of the mucosa in the middle ear cavity and plays a role in the onset, growth, spread, and recurrence of cholesteatoma. Objectives The objective of this study is to investigate the systemic inflammatory effect in chronic otitis with cholesteatoma. Methods The study included a total of 311 patients comprising 156 patients with a ...

In terrestrial mammals, hearing starts with the perception of acoustic pressure by the tympanic membrane. Vibrations in this membrane are then transduced into the inner ear by the ossicle chain of the middle ear, composed of the malleus, incus and stapes. The proper connection of the ossicle chain with the tympanic membrane, provided by the insertion of the manubrium of the malleus into the ear...

Because the microenvironment that supports hematopoietic stem cell (HSC) proliferation and differentiation is not fully understood, we adapted a heterotopic bone formation model as a new approach for studying the HSC microenvironment in vivo. Endogenous HSCs homed to tissue-engineered ossicles and individually sorted HSCs from ossicles were able to reconstitute lethally irradiated mice. To furt...

Radiol Bras. 2014 Mar/Abr;47(2):VII Mass on the dorsal aspect of the wrist, either with or without associated pain, is a frequent complaint in orthopedic surgeon daily practice. In such cases, synovial or ganglion cyst is the most common diagnosis, but this is not the only diagnosis for that condition, so it is very important to know the differential diagnoses. Dorsal wrist mass may originate f...

Meniscal Ossicle are a rare clinical entity with an incidence of only 0,15% [1]. However, it may cause functional limitations and its diagnosis is confused with other knee pathologies. We shall share here our experience in the diagnosis and surgical treatment of a case of meniscal ossicle by arthroscopy, utilizing the anterolateral and anteromedial portals, with intercodylar and posteromedial p...

Audiograms in air and underwater, determined by previous workers for four pinniped species, two eared seals (Otariidae) and two phocids (Phocidae), are supplemented here by measurements on their middle ear ossicular mass, enabling mechanistic interpretations of high-frequency hearing and audiogram differences. Otariid hearing is not largely affected by the medium (air/water). This indicates tha...

Peroperative findings in 145 consecutive cases of chronic suppurative otitis media, operated at Civil Hospital, Karachi were recorded. The mean age was 24 years. More than half of the patients (51%) had subtotal perforations and majority had damage of more than one ossicle. Involvement of all the three ossicles was seen in 30 (40%) cases. The frequency of damaged malleus along with incus was hi...