BACKGROUND This study compared the effect of inhaled fluticasone propionate (FP) with the combination of salmeterol/fluticasone propionate (SFC) on lung function parameters in patients with mild asthma. METHODS Adult patients with mild persistent asthma (> or = 80% predicted FEV1) receiving 200-500 mug of BDP or equivalent were randomised to receive either FP 100 mug or SFC 50/100 mug twice d...

The forced oscillation technique makes it possible to evaluate the mechanical properties of the respiratory system with a minimum of cooperation. The method is therefore especially useful in children. Impulse oscillometry (IOS) is a commercially available version of this technique. There is, as yet, limited information on reference values for IOS in children. The aim of this study was to extend...

This paper presents some results on the correlation between the electrophysiological and intrinsic optical signals (IOS) of spreading depression waves in chicken retinae. We first show that the peak of the time derivative of the electrophysiological wave occurs precisely when the optical signal reaches the electrode tip. Second, by comparing bath applications of propranolol and glycerol it can ...

BACKGROUND Impulse oscillometry (IOS) has previously been proposed to provide greater sensitivity than spirometry when employed with indirect bronchoprovocation testing for the diagnosis of airway dysfunction in athletes. However, this recommendation is based on a highly selected population of symptomatic patients. OBJECTIVE To compare IOS, spirometry and respiratory symptoms following indire...

the impulse oscillation system (ios) measures respiratory impedance (zrs) in terms of resistance (rrs) and reactance (xrs) at multiples of 5 hz. these measurements can be used clinically to help diagnose and monitor respiratory disorders, independent of effort. there is, as yet, no information on reference values for ios in iranian adolescents. the predictive equation for resistance and impedan...

Clinical trials in patients with airway diseases often use forced expiratory volume in 1 s (FEV1) as the sole physiological outcome measure. However, FEV1 is thought to be insensitive to obstruction of the smaller airways, which may be particularly relevant in asthma [1]. Putative markers of small airway obstruction include measures of airway resistance using impulse oscillometry (IOS) [2] and ...

BACKGROUND Small airways play important roles in the pathophysiology of asthma. However, relationships between small airway involvement and health status and dyspnea have not been investigated. OBJECTIVES It was the aim of this study to assess the relationships between proximal and peripheral airway functions and health status, dyspnea and disease control in patients with asthma, using impuls...

PURPOSE High-sensitivity assays enabled the identification of C-reactive protein (hs-CRP) at levels that were previously undetectable. We aimed to determine if hs-CRP could reflect airway inflammation in children, by comparing hs-CRP with spirometry and impulse oscillometry (IOS) parameters and symptomatic severities. MATERIALS AND METHODS A total of 276 asthmatic children who visited Severan...

This study was aimed to evaluate the impulse oscillometry (R20/X5 in patients with COPD in Tehran, Iran. In a retrospective cross sectional study, we selected 101 patients who had PFT and impulse oscillometry records. We considered three groups for patients on the basis of spirometric findings: mild (FEV1 > 75%), moderate (FEV1 = 50%-75%), and severe (FEV1 < 50%) with FEV1/FVC <70% in all the g...

BACKGROUND Remodeling of the peripheral airways persists during the asymptomatic phase of heaves. Assessing the histology of large bronchi could facilitate the diagnosis of heaves during remission of the disease. HYPOTHESIS Airway inflammation and remodeling in endobronchial biopsy (EBB) specimens differentiate horses with heaves from controls, independently of their clinical status (exacerba...