Oral microbiota is among the most assorted in human body. In excess of 700 species have been distinguished mouth, and new sequencing techniques are permitting us to find significantly more species. The life structures oral cavity not same as that other body locales. has mucosal surfaces (the tongue, buccal mucosa, gingiva, palate), hard tissues teeth), exocrine organ tissue (major minor salivar...

BACKGROUND Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use. METHODS We clinically reviewed 89 patients with oral tongue cancer. Exomic sequencing of tumor DNA from 6 nonsmokers was performed and compared to previously sequenced cases. RNA from 20 tumors was evaluated by massively parallel sequencin...

Background and objective Oral tongue Squamous Cell carcinoma (SCC) commonly involves males between the sixth to eighth decades of life. Major risk factors are tobacco usage and alcohol consumption. The increasing number of patients developing oral tongue cancer without these well-known risk factors suggests that a viral infection, such as Human Papillomavirus (HPV), may be responsible for this ...

BACKGROUND Risks of perineural invasion (PNI) in T1-2 oral tongue squamous cell carcinoma (SCC) have not been specifically elucidated. METHODS Pathological features, including PNI, were re-reviewed under regular hematoxylin-eosin staining in 190 patients with T1-2 oral tongue SCC. RESULTS Tumor thickness >5 mm, PNI(+), and lymphovascular invasion (+) independently predicted lymph node invol...

Introduction:Cancer is the second cause of death in the world and the third primary cause in Iran. In this study, we examined the epidemiology of oral squamous cell carcinoma (OSCC) as the most common malignancy of the oral cavity and its related factors in Yazd Province, Iran, from 2001 to 2011. Materials and methods: This descriptive study evaluated the medical records of patients with OSCC ...

BACKGROUND Oral (mobile) tongue squamous cell carcinoma (SCC) is characterized by a highly variable prognosis in early-stage disease (T1/T2 N0M0). The ability to classify early oral tongue SCCs into low-risk and high-risk categories would represent a major advancement in their management. METHODS Depth of invasion, tumor budding, histologic risk-assessment score (HRS), and cancer-associated f...

Imaging plays a crucial role in the staging of oral cancers. Imaging information is essential for determining tumour resectibility, post resection surgical reconstruction and radiation therapy planning. The aim of this paper is to highlight the natural history of oral cancer spread and how malignant infiltration can be accurately mapped. It focuses on buccal mucosa, hard palate, tongue and floo...

We recently encountered an unusual case of squamous cell carcinoma in the left of lingual body arising in a 29-year-old woman who had a history of systemic lupus erythematosus. The woman had been diagnosed as systemic lupus erythematosus for five months during which the treatment for lupus was carried out. Five months later, she went to our department of oral surgery for the treatment of “tongu...

Incidences of oral tongue, base of the tongue, and tonsil cancers have been increasing steadily in many parts of the world in spite of declining rates of tobacco use over the last four decades. A better understanding of the etiology, interactions between risk factors, and new approaches to prevention and treatment are necessary to change this course. This paper will present evidence supporting ...

Background and Aims. There is evidence of differences in p63 expression in HNSCC (head and neck squamous cell carcinoma) tumours of different sub-sites within the oral cavity which appear to have an important role in CD44 regulation. The aim of this study was to investigate CD44 expression in HNSCC tumours in different areas of the oral cavity. Methods. Formalin-fixed and paraffin-embedded oral...