A 35 year woman G2P0A1L0 at 16 weeks period of gestation, underwent termination of pregnancy for a fetus having a large lumbosacral meningomyelocele and Arnold chairi II malformation. She was a known treated case of tuberculoma of the brain who was not on any antiepileptics, and had been seizure free for the past two years. She developed two episodes of seizures precipitated during pregnancy te...

OBJECTIVE To compare two methods for induction of second-trimester abortion after priming the cervix with mifepristone. METHODS This was a randomized prospective trial carried out between January 2009 and February 2012. The participants were healthy women between 14 and 24 weeks of gestation with missed miscarriage or need for termination of pregnancy. All participants received oral 200 mg mi...

Clinical use of drugs is approved for specified clinical indication, route of administration, dose and population group. Off-label prescribing of a registered medicine occurs outside of these parameters and may be justified by pharmacology and physiology, as well as sufficient evidence from published clinical trials and reviews. Misoprostol and mifepristone in combination have recently been reg...

OBJECTIVES To determine the efficacy of 400 mcg sublingual misoprost as an adjunct to suction evacuation in first trimester pregnancy termination. METHOD(S) During the study period of January2006-June 2007, two hundred twenty-one pregnant women wanting first trimester pregnancy termination were randomised into two groups. In the study group of one hundred twenty-one women, sublingual misopros...

Prostaglandins have revolutionalized obstetric practice. In particular, the advent of misoprostol has precipitated an enormous amount of innovative research as well as controversy. At present, misoprostol is being simultaneously investigated for its role in the management of postpartum hemorrhage (PPH), induction of labor, cervical ripening and termination of pregnancy. Initially, this drug was...