OBJECTIVE A study was carried out to compare 3 treatment regimens for vaginal candidiasis. METHODS A total of 150 women with clinical and mycological evidence of vaginal candidiasis were randomized to receive 50 mg of oral fluconazole daily for 6 days (50 women), a single oral 150 mg dose of fluconazole (50 women), or 100 mg of intravaginal clotrimazole daily for 6 days (50 women). They were ...

Among leukemia patients, a significant number of deaths are due to Candida septicemia, many of which are associated with previous oral infections. Oral candidiasis detection methods vary, and the relationship between oral candidiasis and Candida colonization (CC) is not well defined. The main objectives of this study were to compare the incidence of CC in a healthy and leukemic population, and ...

Secreted aspartyl proteinases are putative virulence factors in Candida infections. Candida albicans possesses at least nine members of a SAP gene family, all of which have been sequenced. Although the expression of the SAP genes has been extensively characterized under laboratory growth conditions, no studies have analyzed in detail the in vivo expression of these proteinases in human oral col...

Background: Oral lesions are among the earliest clinical manifestations of human immunodeficiency (HIV) infection and are important in early diagnosis and for monitoring the progression to acquired immunodeficiency syndrome (AIDS). The purpose of this study was to determine the prevalence of oral lesions and their relationship with a number of factors in HIV/AIDS patients attending an HIV cente...

Candidiasis, a common opportunistic and important fungal infection of the oral cavity is caused by Candida species. There are some local risk factors mainly acidic saliva, dry mouth, use of prosthetic dentures at night, tobacco, carbohydrate rich-diets and patients receiving radiotherapy and chemotherapy in maxillofacial regions that make the oral cavity more prone to Candida infection. Oral hy...

Sir, Recently, De Giorgi V et al. published an interesting clinical picture titled ‘Hyperplastic oral candidiasis of the tongue’. I read this article with great interest and compliment the authors for their clinical report. However, I would like to highlight several important issues. We should analyze carefully when the authors state, ‘Clinically, it is nearly impossible to differentiate such l...

INTRODUCTION This study assessed the prevalence of hypovitaminosis D and its association with oral candidiasis and clinical parameters of periodontitis (CPP) in HIV-infected patients. METHODS Periodontal examinations for the 113 HIV-infected patients were recorded using the Community Periodontal Index. A cytological smear from the lateral borders of the tongue was performed to evaluate candid...

Oral candidiasis is a significant health problem in terms of both morbidity and economic outlay. Infections are predominantly caused by the commensal C. albicans, and affect immunocompromised individuals, including HIV-positive and AIDS patients, organ transplant recipients and chemotherapy patients. The molecular and cellular immune mechanisms involved in protection from and responses to oral ...