Few cancers are diagnosed based on RNA expression signatures. Oral squamous cell carcinoma (OSCC) is no exception; it is currently diagnosed by scalpel biopsy followed by histopathology. This study sought to identify oral tumor epithelial microRNA (miRNA) expression changes to determine if these changes could be used to diagnose the disease noninvasively. Analysis of miRNA profiles from surgica...

One of the roles of a dental practitioner is the identification and management of oral mucosal disease (pathology) in its many forms. A tissue biopsy is an important step in the diagnostic process for oral lesions, while the skill required to perform a biopsy should be well within the capability of most practising dentists. The purpose of this article is to help dental practitioners to identify...

Formalin is a hazardous chemical, yet it is the choice of fixative for diagnostic pathology. Dental surgeons routinely use formalin for preservation of oral biopsy specimens. Literature search revealed that during regular biopsy procedures, unintentional injection with formalin has occurred, and such rare seven cases have been reported till date. In addition to the literature review, the presen...

Biopsy is a useful technique for definitive diagnosis of abnormal oral conditions and it must be performed carefully since any error may result in histopathologic misidentification of the lesion. Present study evaluated the most relevant literatures published between 1982 and 2012 in order to review existed guidelines of correct biopsy performance using scientific database sources such as PubMe...

It has been reported by us and by others that after chemotherapy for Hodgkin's disease the ovary contains fewer than 5 primordial and primary follicles per 5 x 5 mm biopsy section. In young women this is associated with premature menopause. We report here that before treatment the tissue contains 18--55 such follicles per biopsy section. When women took combination oral contraceptives throughou...

oral malignant melanoma (omm) accounts for 5% of all oral malignancies. it is a rare aggressive neoplasm usually found on the hard palate and gingiva. the etiology is unknown, but tobacco and chronic irritation are suggested as probable causative factors. over 30% of the cases have been reported to arise from pre-existing pigmented lesions. a biopsy is required to establish the diagnosis and th...

Biopsy is the gold standard of diagnostic procedures. The American Academy of Oral and Maxillofacial Pathology has stated its position concerning biopsy use in dental practice, believing that using the procedure more frequently will enhance diagnosis and contribute substantially to the quest for more evidence-based practice. Biopsy is a technique within the scope of practice of general dentists...

peripheral ossifying fibroma is one of the commonest occurring reactive lesions on gingiva. it is associated with local irritational factors and often interferes with speech, mastication and maintenance of oral hygiene, in addition to being aesthetically unpleasant. it is usually treated with surgical excision using scalpel and removal of irritational factors, often resulting in mucogingival de...

A definitive diagnosis is crucial for management of any oral mucosal disease. Direct immunofluorescence (DIF) is a valuable diagnostic aid for immune-mediated blistering diseases and systemic connective tissue diseases of the skin and the mucosa. This paper gives an overview of the DIF biopsy technique for oral lesions and provides a background for the clinician to optimize the utilization of D...