In this paper an optimization framework is presented for automated performance-based seismic design of bridges consisting of multi-column RC pier substructures. The beneficial effects of fusing components on seismic performance of the quasi-isolated system is duly addressed in analysis and design. The proposed method is based on a two-step structural analysis consisting of a linear modal dynami...

Interior point methods have proven very successful at solving linear programming problems. When an explicit linear programming formulation is either not available or is too large to employ directly, a column generation approach can be used. Examples of column generation approaches include cutting plane methods for integer programming and decomposition methods for many classes of optimization pr...

The development of high-resolution liquid chromatography (LC) is essential for improving the sensitivity and throughput of mass spectrometry (MS)-based proteomics. Here we present systematic optimization of a long gradient LC-MS/MS platform to enhance protein identification from a complex mixture. The platform employed an in-house fabricated, reverse-phase long column (100 μm × 150 cm, 5 μm C18...

Preliminary layout design of buildings has a substantial effect on the ultimate design of structural components and accordingly influences the construction cost. Exploring structurally efficient forms and shapes during the conceptual design stage of a project can also facilitate the optimum integrated design of buildings. This paper presents an automated method of determining column layout desi...

introduction: hepatitis c virus (hcv) is the major cause of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma worldwide. because of increasing number of infected patients throughout the world, various studies are concentrated on development of high quality diagnostic tests and genotyping in various regions of the world. methods: in this study, we used rt-pcr to isolate and a...

An in-depth numerical study has been carried out to investigate a high-pressure commercial scale (2–8 meter diameter) slurry bubble column reactor (SBCR). Typical superficial gas velocities are in the range of 0.5–3 m/s, and overall vapor hold-ups are in the range of 0.45–0.85. The study revealed that steady compartmental reaction models do not match plant data when reaction time constants are ...

Distillation columns with a high-purity product (down to 7 ppm) have been studied. A steady state model is developed using a commercial process simulator. The model is validated against industrial data. Based on the model, three major optimal operational changes are identified. These are, lowering the location of the feed & side draw streams, increasing the pressure at the top of the distillati...