BACKGROUND The observation of a buildup of mitochondria at the level of the lamina cribrosa in the optic nerve head has traditionally been attributed to axoplasmic stasis. However, this region is also the transition zone for myelination, resulting in differing energy requirements. OBJECTIVE To investigate the relationship between myelination and mitochondrial activity in optic nerve tissue. ...

purpose : to report two patients with spontaneous scleral perforation and bleb formation associated with marfan syndrome (mfs) which one of them also showed bilateral optic nerve dural ectasia. case reports : an 11-year-old girl was referred with progressive myopia. past medical history was negative. slit-lamp examination revealed bilateral scleral thinning and perforation with bleb formation, ...

introduction penetration of a bicycle brake handle into the orbit is a rare and serious type of trauma. globe subluxation due to such trauma has not been previously reported. case presentation a 10-year-old girl presented after falling from a bicycle, which resulted in the handbrake penetrating her right upper eyelid. on examination, the globe was subluxated anteriorly, there was no light perce...

OBJECTIVE Optic atrophy is a pathological term applied to optic nerve shrinkage from any process that produces degeneration of axons in the anterior visual system (the retino-geniculate pathway). The pathologist can make the diagnosis of optic atrophy by direct observation of the histopathological changes in the optic nerve. The clinician is restricted to indirect evidence by observing the opti...

Optic neuritis is commonly associated with diseases such as Multiple Sclerosis, infections, taking special drugs, etc. but recently we have observed a patient that presented retro bulbar optic neuritis as a manifestation of antiphospholipid syndrome. A 35 y/o young woman with the history of chickenpox admitted to the Qhaem hospital (Mashhad, Iran) with the c/o progressive pain and blurred visio...

introduction: elevated intracranial pressure (icp) is a major and potentially lethal disorder in patients admitted to the emergency department (ed). several methods are being used to investigate for elevated icp. here we assessed and compared the diagnostic accuracy of two existing tools of ophthalmoscopy and optic nerve ultrasonography in detection of elevated icp. methods: 131 participants wi...

OUGH the havoc wroumght by blindness is not part of the classical picture of pernicious anemia, an occasional Victim of this disease becomes blind from an optic nerve lesion. In America, little attention has been given to this complication. In 1897, Bastianelli’ reported a patient with anemia, spastic paraplegia and optic nerve atrophy, and thereafter sporadic reports of optic atrophy in patien...

multiple sclerosis (ms) is the most prevalent disease caused by the inflammatory demyelinating process that causes progressive nervous system degeneration over the time. optical coherence tomography (oct) is a non-invasive optical imaging technology, which can measure the thickness of retinal nerve fiber layer as well as the diameter of the macula. the purpose of the study is evaluation oct fin...

PURPOSE To determine whether tumor size correlates with histopathological involvement and hence evaluate the rationality of conservative treatment for retinoblastoma. METHODS We retrospectively studied 221 patients (221 eyes) treated for retinoblastoma with enucleation in the Zhongshan Ophthalmic Center of Sun Yat-sen University, China, from October 1995 to December 2004. Histopathological da...

Neurodegeneration plays a major role in multiple sclerosis (MS), in which it is thought to be the main determinant of permanent disability. However, the relationship between the immune response and the onset of neurodegeneration is still a matter of debate. Moreover, recent findings in MS patients raised the question of whether primary neurodegenerative changes can occur in the retina independe...