Optic neuritis has been described among the toxic effects of Ethambutol. This side effect is dose related. The mean duration of Ethambutol induced optic neuritis (EON) is three months. We report a case of EON after few days of exposure to Ethambutol and the symptoms resolved after discontinuation of Ethambutol. This most likely represents an idiosyncratic reaction which is different as compared...

The effect of the finite extinction ratio of an electro-optic modulator (EOM) on the Brillouin frequency measurement of a distributed Brillouin-based fiber optic sensor is studied. An EOM with a finite extinction ratio limits the application of Brillouin optical time domain analysis in a distributed Brillouin-based fiber optic sensor. This results in confusion in specifying the location of the ...

PURPOSE To determine whether inducible nitric oxide synthase (NOS-2) is involved in glaucomatous optic neuropathy. METHODS Chronic elevation of rat intraocular pressure (IOP) leading to optic nerve damage was induced by episcleral injection of hypertonic saline, which caused sclerosis and blockade of aqueous humor outflow pathways. Expression of NOS-2 in the retina and optic nerve head (ONH) ...

inconclusive because of small sample size. In the 1980s, the Optic Neuritis Treatment Trial was developed to evaluate corticosteroid treatment for optic neuritis. This multicenter randomized clinical trial, supported by the National Eye Institute, was designed to answer the following questions: (1) Does treatment with either oral prednisone or intravenous methylprednisolone followed by oral pre...

An automated segmentation system of the optic radiation using diffusion tensor imaging (DTI) is proposed. The DTI-data is interpolated in the Log-Euclidean framework to avoid the swelling effect and regularized by diffusion filtering. Based on physiological and anatomical information, robust initial estimates of the optic radiation and the midbrain are obtained using thresholding and connectivi...

The histopathologic effects of methanol on the optic nerve were studied in four patients. Circumscribed myelin damage occurred behind the lamina cribrosa in each nerve. Axons were preserved. Demyelination also occurred in cerebral hemispheric white matter in one patient. This selective myelinoclastic effect of methanol metabolism is probably caused by histotoxic anoxia in watershed areas of the...

We designed and fabricated a four-channel reconfigurable optical add-drop multiplexer based on silicon photonic wire waveguide controlled through thermo-optic effect. The effective footprint of the device is about 1000 x 500 microm(2). The minimum insertion loss is about 10.7 dB and the tuning bandwidth about 17 nm. The average tuning power efficiency is about 6.187 mW/nm and the tuning speed a...

PURPOSE Dominant optic atrophy (DOA) is the most common form of autosomal inherited optic neuropathy, mainly caused by mutations in the optic atrophy 1 (OPA1) gene. The purpose of this study was to detect OPA1 gene mutations and associated phenotypes in Chinese patients with suspected hereditary optic neuropathy. METHODS A cohort of 193 Chinese families with suspected hereditary optic neuropa...

A technique for measuring the Faraday effect and the magneto-optic Kerr effect has been developed. In a Sagnac interferometer, two optical beams follow identical paths in opposite directions. Effects which break time-reversal symmetry, such as magneto-optic effects, will cause destructive interference between the two beams. By measuring the phase shift between circular polarization states refle...

PURPOSE Biomechanical factors have been implicated in the development of glaucomatous optic neuropathy, particularly at the level of the lamina cribrosa. The goal of this study was to characterize the biomechanics of the optic nerve head using computer modeling techniques. METHODS Several models of the optic nerve head tissues (pre- and postlaminar neural tissue, lamina cribrosa, central reti...