Microspheres formulated from poly (D,L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres ...

Inside a case-based system, a case c is represented by a set of information entities ei E: c = {e1, e2, ..., en}. It is compared with a query q that is as well just a set of information entities. A composite similarity function for q, c ⊆ E determines a numeric value for the degree of similarity SIM(q, c). SIM is computed by means of a local similarity function sim : E × E → R. A very simple ex...

BACKGROUND Combination therapy with sofosbuvir (SOF) and simeprevir (SIM) is used to treat patients with hepatitis C virus infection. It is currently unknown whether adding ribavirin (RBV) to SOF + SIM, which raises the pill count from two up to eight pills a day, impacts adherence. The aim of this study is to examine the impact of pill count on real-world adherence rates in patients treated wi...

Cell differentiation is generally tightly coordinated with the cell cycle, typically resulting in a nondividing cell with a unique differentiated morphology. The unicellular trichomes of Arabidopsis are a well-established model for the study of plant cell differentiation. Here, we describe a new genetic locus, SIAMESE (SIM), required for coordinating cell division and cell differentiation durin...

Data collected by the International Arctic Buoy Programme from 1979 to 1998 are analyzed to obtain statistics of sea level pressure (SLP) and sea ice motion (SIM). The annual and seasonal mean fields agree with those obtained in previous studies of Arctic climatology. The data show a 3-hPa decrease in decadal mean SLP over the central Arctic Ocean between 1979–88 and 1989–98. This decrease in S...

Structured illumination microscopy (SIM) is a method in fluorescence microscopy which works by acquiring a set of images using widefield detection. Each image in the set is made with a different position of an illumination mask, but with no mask in the detection path [1]. Subsequent image processing is used to produce an optically sectioned image (OS-SIM) [2 4], or an image with resolution beyo...

v As we celebrate during the approaching holidays with loved ones and friends, we have much to be thankful for. The year 2004 has been outstanding for SIM and for MISQE. Our partnership has flourished, one example being the SIM white paper winners, which represent successful practitioner projects. In this edition of MISQE you will find the first place finisher, a paper titled " Innovation throu...

Recently we isolated a homolog of the Drosophila single-minded (sim) gene from a zebrafish cDNA library. The 4380-bp of zebrafish sim cDNA encodes a polypeptide of 585 amino acids with strikingly conserved bHLH and PAS A/B domains in the amino-terminal region. During embryogenesis, sim mRNA appears in the animal hemisphere as early as 3 h post-fertilization and is expressed in a widespread patt...