Knowledge of the polyprotein cleavage sites by HIV protease will refine our understanding of its specificity, and the information thus acquired is useful for designing specific and efficient HIV protease inhibitors. The pace in searching for the proper inhibitors of HIV protease will be greatly expedited if one can find an accurate, robust, and rapid method for predicting the cleavage sites in ...

Sequential oligopeptides prepared by condensation of peptides with the sequence Ala-Pro-Gly or Gly-Pro-Gly were examined as possible substrates or inhibitors for the synthesis of hydroxyproline by protocollagen proline hydroxylase. The tripeptide BOC-Ala-Pro-Gly-OMe (where BOC-represents 1-butoxycarboxyland Me represents methyl) was not hydroxylated, but oligopeptides ranging in size from BOC(A...

Oligopeptides that mimic segments of the amino acid sequence of hemoglobin S at potential contact sites can be used to inhibit aggregation. These oligopeptide inhibitors raise the minimum gelling concentration of deoxyhemoglobin S so that chemical modification does not have to be used. The hexapeptide amides of both betaS 1-6 which is believed to be one of the contact areas among aggregates, an...

The design and synthesis of new molecules having various functions, which can not be attained by using natural products, have attracted much attention from organic, bioorganic, peptide, and medicinal chemists. The creation of such intelligently functionalized molecules is a new research area of chemistry in the 21st century. One category of such molecules might be ‘foldamers’, as named by Gellm...

Understanding the dynamic behavior of switchable surfaces is of paramount importance for the development of controllable and tailor-made surface materials. Herein, electrically switchable mixed self-assembled monolayers based on oligopeptides have been investigated in order to elucidate their conformational mechanism and structural requirements for the regulation of biomolecular interactions be...

A detailed understanding of themechanistic principles which govern peptide and protein selfassembly is of considerable biomedical and biotechnological importance. Owing to the diversity of peptide and protein sequences which have been shown to aggregate into ordered structures, the ability to self-assemble is now recognized as an inherent feature of the polypeptide backbone. It is therefore of ...