against several kind of sickness including cancer, gastric ulcers, dyspepsia and also useful as an antibacterial and antiinflammatory. Sesquiterpenes, triterpenes, quinone-methide and sesquiterpene pyridine alkaloids have been identified in these species. Maytenus obtusifolia MART. is a plant found in many states of the Northeast and South-east of Brazil, which is used in traditional medicine f...

Cell suspension cultures from hypocotyl-derived callus of Hyssopus officinalis were found to produce two sterols i. e. beta-sitosterol (1) and stigmasterol (2), as well as several known pentacyclic triterpenes with an oleanene and ursene skeleton. The triterpenes were identified as oleanolic acid (3), ursolic acid (4), 2alpha,3beta-dihydroxyolean-12-en-28-oic acid (5), 2alpha,3beta-dihydroxyurs...

the plant kingdom. A variety of biological properties have been ascribed to this class of compounds including antiinflammatory, hepatoprotective, gastroprotective, anti-ulcer, anti-HIV, anti-cancer, anti-diabetic, hypolipidemic, antiatherosclerotic and immunoregulatory effects. As a part of our project aimed at drug discovery based on pharmacological interference with glucose metabolism, we hav...

Pentacyclic triterpenes, mainly, asiatic acid, madecassic acid, asiaticoside, and madecassoside are the active constituents of Centella asiatica. A pentacyclic triterpene enriched C. asiatica extract (PRE) was prepared and standardized to contain a total pentacyclic triterpenes not less than 65% w/w. This work was focused on determination of antiinflammatory, antioxidant, and tyrosinase inhibit...

BACKGROUND Cytochrome P450- and ω-hydrolase products (epoxyeicosatrienoic acids (EETs), hydroxyeicosatetraeonic acid (20-HETE)), natural omega-3 fatty acids (ω3), and pentacyclic triterpenes have been proposed to contribute to a wide range of vaso-protective and anti-fibrotic/anti-cancer signaling pathways including the modulation of membrane ion channels. Here we studied the modulation of inte...

BACKGROUND & OBJECTIVES Ciprofloxacin is commonly used in clinical practice for the treatment of recurrent urinary tract infections caused by Escherichia coli. However, very often these recurrent infections are due to a failure in a complete eradication of the microorganisms colonizing the urinary tract, especially in catheterized patients. To enhance the bactericidal activity of ciprofloxacin ...

Pentacyclic triterpenic compounds including asiatic, betulinic, maslinic, oleanolic and ursolic acid occur naturally in many herbs and plant foods. It is well known that these triterpenoids possess anti-oxidative and anti-inflammatory activities. Furthermore, recent in vitro and in vivo researches indicated that these compounds could inhibit the production of advanced glycation end-products (AG...