Adenomatoid odontogenic tumors are considered, rather than a neoplasia, a benign, hamartomatous epithelial lesion of odontogenic origin . Steensland fi rst described it in 1905; he considered it as a variation of ameloblastoma.1 Stafne, in 1948 described it as an «ameloblastic adenomatoid tumor or adenoameloblastoma»,2 since it presented structures which simulated canals or glands, he therefore...

Calcifying cystic odontogenic tumor (CCOT) is defined as an odontogenic cyst-like benign neoplasm that characteristically contains several ghost cells, ameloblastoma-like epithelium, and occasional calcification. Ghost cell odontogenic carcinoma (GCOC), a malignant form of CCOT, is an exceptionally rare malignant tumor. In this report, we present a case of a 53-year-old man whose chief complain...

BACKGROUND Origin of adenomatoid odontogenic tumor (AOT) has long been a controversy, and the issue of it being a neoplasm or hamartoma was a subject of debate for a long time. Earlier it was grouped under a mixed group of odontogenic tumors considering the varying degrees of inductive changes. Recently, the WHO classification states that the presence of hard tissue within AOT was not due to in...

Ameloblastic fibrodentinoma is a benign odontogenic tumor belonging to the category of "odontogenic epithelium with odontogenic ectomesenchyme" along with recognition of induction in the form of dentin in atypical or dysplastic forms. The biological behaviour of ameloblastic fibrodentinoma is not very different from ameloblastic fibroma; hence, it is treated similarly by conservative procedures...

Orthokeratinized odontogenic cysts (OOCs) are relatively uncommon developmental cysts lined with orthokeratinized epithelium consisting of a prominent granular layer and a basal layer of low cuboidal flattened cells that show no tendency for nuclear palisading. These cysts have been considered a distinct entity from odontogenic keratocysts since they exhibit a less aggressive behavior and a ver...

Introduction: Oral verrucous carcinoma (OVC) is a rare malignancy of the oral cavity that was first described by Ackerman. This tumor is a well-differentiated low-grade, slow growing cancer that is locally invasive without metastasis. Ameloblastoma is one of the most common odontogenic tumors, which originates from the odontogenic epithelium. Verrucous carcinoma along with central ambloblastoma...

Soft tissue myxoma of the oral cavity is extremely rare. We present a case of soft tissue myxoma arising from a mandibular anterior gingiva in a 51-year-old male patient. Histological examination showed islands of odontogenic epithelium scattered in the mucinous stroma. This lesion was supposed to have a odontogenic origin. The clinical differences between soft tissue myxoma with bone destructi...

Tooth development is a multi-stage and multi-step process involving fate determination morphogenetic patterning events, epithelial-mesenchymal interactions, cell proliferation, differentiation, migration. Animal model studies have shown that YAP TAZ, effectors of the Hippo pathway, critical function in tooth morphogenesis. However, TAZ has not been well documented its specific roles morphogenes...

Introduction: Adenomatoid odontogenic tumor since years has been a subject for diligent research by Oral Medicine and Radiologists and Oral Pathologists in the past. Adenomatoid odontogenic tumor is a benign hamartomatous slow growing neoplasm of epithelial origin composed of odontogenic epithelium in a variety of histoarchitectural patterns, embedded in a mature connective tissue stroma and ch...

AIM Though odontogenic lesions have in common origin from the primitive odontogenic epithelium , there is a diversity in their initiation behavior and growth. The aggressive nature of odontogenic keratocyst similar to ameloblastoma in comparision with the other common odontogenic (dentigerous and radicular) cyst could be due to possible differences in their epithelial linings. PCNA (Proliferati...