A useful pharmaceutical intermediate, 5-nitromethyl-1-azabicyclo[3.3.0]octane (1), was prepared in one step from 1,7-dichloro-4-heptanone (4) under mild conditions. Catalytic hydrogenation of 1 over Raney Ni in the presence of sodium hydroxide afforded 5-aminomethyl-1-azabicyclo[3.3.0]octane (2) in high yield. Piracetam analogues 20-23, which were pyrrolidine derivatives involving a 1-azabicycl...

Tri-n-butyl phosphate (TBP) is an important extractant for heavy metal ions. The microscopic structure of TBP/n-octane mixtures as a function of concentration of TBP is examined through atomistic molecular dynamics simulations. A weak association between TBP molecules both in pure TBP as well as in the octane solution is established. In dilute TBP/n-octane solutions, TBP molecules are inhomogen...

Methyl tert-butyl ether (MTBE) was originally introduced as an additive to increase octane number into gasoline in the 1970s. Its use was primarily as an octane enhancer to replace lead in gasoline. Later on, it was also used as an oxygenate, up to 15% v/v, to accomplish a cleaner burning fuel with reduced emissions of carbon monoxide and hydrocarbons. The problem with MTBE is that it has cause...