background ochratoxin a (ota) is a toxic secondary metabolite produced by fungi belonging to aspergillus and penicillium genera. the production of ota is influenced by environmental conditions and nutritional requirements. the postharvest application of bunches of table grape fruit (tgf), with water activity of 0.8 aw, was highly effective for controlling ota contamination in vitro and in vivo ...

Ochratoxins are a group of mycotoxins produced by a variety of moulds. Ochratoxin A (OTA), the most prominent member of this toxin family, was first described by van der Merwe et al. in Nature in 1965. Dietary exposure to OTA represents a serious health issue and has been associated with several human and animal diseases including poultry ochratoxicosis, porcine nephropathy, human endemic nephr...

The effects of four alkaloids on the biosynthesis of ochratoxin A (OTA), ochratoxin B (OTB) and citrinin were examined on four OTA-producing aspergilli: Aspergillus auricomus, A. sclerotiorum and two isolates of A. alliaceus. Piperine and piperlongumine, natural alkaloids of Piper longum, significantly inhibited OTA production at 0.001% (w/v) for all aspergilli examined. Piperine and piperlongu...

This study aimed to evaluate the effect of dietary ochratoxin, in the presence or absence of aluminosilicate, on the histology of the bursa of Fabricius, liver and kidneys, and on the humoral immune response of broilers vaccinated against Newcastle disease virus. The exposure of birds to 2 p.p.m. ochratoxin, in the presence or absence of aluminosilicate, reduced their humoral immune response an...

Effect of Thyme Alcoholic Extract on Reducing Aflatoxin and Ochratoxin Toxicity in Broiler Chickens

The present study was undertaken to study the combined effect of Aflatoxin and Ochratoxin A on liver enzymes of broilers and the amelioration of the effects using adsorbents. Aflatoxin and ochratoxin A were mixed with the broiler diet to attain a concentration of 1 ppm and 2 ppm respectively. Activated charcoal at 0.4% and lyophilized yeast culture at 0.2% level were used as adsorbents for test...

A method is described for ochratoxin B analysis, which is adapted to the earlier described method of ochratoxin A analysis, using carboxypeptidase A (K. Hult and S. Gatenbeck, J. Assoc. Off. Anal. Chem. 59:128-129, 1976). The fluorescence spectra of ochratoxins A and B coincide too much to allow direct discrimination of the two compounds. A method using the differences in kinetic parameters of ...

the objective of this study was to assess the microbial contamination of razavi khorasan (iran) hot red pepper. the natural occurrence of aflatoxins and ochratoxin a in those samples was also investigated. for this purpose, 36 samples of this kind of pepper were collected from a farm and sun-dried. standard and established methods were used for both microbiological analyses and mycotoxins ident...

mycotoxins are small, toxic chemical products produced as secondary metabolites by a few fungal spices that readily colonise crops and contaminate them with toxins in the field or after harvest. in this study a liquid chromatographic method was developed for the simultaneous determination of aflatoxins (afs) (b 1 , b 2 , g 1 , and g2), ochratoxin a (ota) and zearalenone(zea) toxins in wheat. fo...

The contamination of consumer food and animal feed with toxigenic fungi has resulted in economic losses worldwide in animal industries. Mycotoxins are highly biologically reactive secondary metabolites and can inhibit protein synthesis and cell multiplication. Considering the cytotoxicity of mycotoxins, this experiment was performed to determine the in vitro influence of ochratoxin A, deoxyniva...