According to WHO, Pharmacovigilance activities are done to monitor detection, assessment, understanding and prevention of any obnoxious adverse reactions to drugs at therapeutic concentration on animal and human beings. However, there is also a growing focus among scientists and environmentalists about the impact of drugs on environment and surroundings. The existing term 'Ecopharmacology' is t...

In this paper we consider the following obnoxious facility location problem: given a set S of n points in the plane, and two special points a and b, find the 1-corner polygonal chain (also known as boomerang) connecting a and b such that its minimum distance to S is maximized. In other words: find the widest empty polygonal chain of two edges having extremes anchored at a and b. We present a ne...

Undesirable taste is one of several important formulation problems that are encountered with certain drugs. The problem of bitter and obnoxious taste of is a challenge to the pharmacist in the present scenario. Several oral pharmaceuticals and bulking agents have unpleasant, bitter-tasting components. The desire of improved palatability in these products has prompted the development of numerous...

Waterhyacinth is one of the fastest growing plants which disrupt the ecological balance. The plant inspite of its obnoxious nature, is a source of various pharmacologically active compounds. Sterols were isolated from the ethyl acetate extract of waterhyacinth and characterized to be a mixture of stigmasterol and β-sitosterol based on UV, IR, 1D and 2D NMR studies. Quantification of the isolate...

Extensive use of indwelling devices in modern medicine has revoked higher incidence of device associated infections and most of these devices provide an ideal surface for microbial attachment to form strong biofilms. These obnoxious biofilms are responsible for persistent infections, longer hospitalization and high mortality rate. Gene regulations in bacteria play a significant role in survival...

A single man aged 65 years was referred to the Department of Venereology in 1949 on account of extensive necrosis of the skull and gangrene of the right foot. The precipitating factor was an obnoxious smell, attributed to a blocked drain, which was reported by some of his neighbours to the local Sanitary Authority. Through the Medical Officer of Health, the patient was eventually compelled to a...